{
  "abstract": "Insulin/IGF signaling (IIS) inhibits the nuclear localization of the DAF-16 /FOXO transcription factor to regulate longevity and stress resistance in C. elegans . In the intestine, IIS promotes DAF-16 localization to endosomes and loss of TBC-2 , a RAB-5 GAP, results in increased endomembrane localization of DAF-16 at the expense of nuclear localization, decreased DAF-16 target gene expression, longevity and stress resistance. Here we found that TBC-2 differentially regulates the localization of the IIS-regulated transcription factors PQM-1 and HLH-30 /TFEB. Our results suggest a broader role for TBC-2 in regulating IIS and that TBC-2 likely functions at an upstream point in the IIS pathway.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada.",
    "Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, QC, Canada.",
    "Metabolic Disorders and Complications Program, RI-MUHC, Montreal, QC, CA."
  ],
  "article_type": "brief report",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Soumyendu Saha"
    },
    {
      "affs": [
        0
      ],
      "name": "Icten Meras"
    },
    {
      "affs": [
        1,
        2,
        0
      ],
      "name": "Christian E Rocheleau"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cn5ty22jfezyv.bib",
  "cited_by": 0,
  "doi": "10.17912/micropub.biology.002470",
  "fulltext_url": "https://europepmc.org/articles/PMC13714644",
  "id": "cn5ty22jfezyv",
  "issns": [
    "2578-9430"
  ],
  "landing_url": "https://europepmc.org/article/MED/42953546",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "C. Elegans"
    ],
    [
      "heading",
      "New Finding"
    ],
    [
      "heading",
      "Phenotype Data"
    ],
    [
      "openalex",
      "1302|Genetics, Aging, and Longevity in Model Organisms"
    ]
  ],
  "openalex": "W7221624738",
  "pdf_url": "https://europepmc.org/articles/PMC13714644?pdf=render",
  "pmcid": "PMC13714644",
  "pmid": "42953546",
  "published": "2026-10-13",
  "publisher": "California Institute of Technology",
  "ris": "https://research.draconitic.com/paper/cn5ty22jfezyv.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:41Z",
      "native_id": "MED:42953546",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42953546"
    },
    {
      "first_seen": "2026-11-01T12:22:06Z",
      "native_id": "PMC13714644",
      "source": "pmc",
      "url": "https://doi.org/10.17912/micropub.biology.002470"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1302|Genetics, Aging, and Longevity in Model Organisms",
      "subfield": "cell-biology"
    }
  ],
  "title": "TBC-2, a Rab GTPase activating protein, regulates the localization of the HLH-30/TFEB and PQM-1 transcription factors in the C. elegans intestine.",
  "title_text": "TBC-2, a Rab GTPase activating protein, regulates the localization of the HLH-30/TFEB and PQM-1 transcription factors in the C. elegans intestine.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:06Z",
  "url": "https://research.draconitic.com/paper/cn5ty22jfezyv",
  "venue": "MicroPublication biology",
  "versions": []
}