{
  "abstract": "RATIONALE AND OBJECTIVES 3D-TOF-MRA is a standard non-invasive method for detecting and monitoring intracranial aneurysms, but long scan times remain a limitation. Compressed sensing (CS) acceleration for intracranial aneurysm evaluation has mainly been studied at 3T. This prospective single-center non-inferiority study compared CS-accelerated 3D-TOF at 1.5T with GRAPPA-accelerated 3D-TOF-MRA for evaluating untreated intracranial aneurysms. MATERIALS AND METHODS Sample size was determined via a preliminary retrospective study. 25 patients with 32 untreated aneurysms underwent both CS- (factor 7, 3:04 min) and GRAPPA-accelerated (factor 2, 5:00 min) 3D-TOF, yielding a 38.7% scan-time reduction. Two blinded neuroradiologists assessed overall image quality (primary endpoint) and artifacts, subjective CNR, aneurysm delineation and diameters (secondary endpoints). Non-inferiority was tested via one-sided t-test (prespecified 10% margin); interrater agreement used ICC. RESULTS CS demonstrated non-inferiority to GRAPPA for overall image quality in both readers (p <= .023), though interrater agreement was low (ICC 0.241-0.262), reflecting subjective variability. Secondary exploratory analyses showed heterogeneous preferences. ROI-based CNR was lower for CS (median 169.6; IQR, 91.0-226. vs. 278.2; 181.0-366.2). Aneurysm diameter measurements showed excellent interrater agreement for both techniques (CS ICC, 0.899-0.980; GRAPPA ICC, 0.877-0.973; all p < .001). CONCLUSION CS-accelerated 3D-TOF at 1.5T met non-inferiority criteria vs. GRAPPA-TOF for overall image quality, reducing scan time by 38.7% while preserving aneurysm measurement reliability. However, reduced CNR and reader-preference variability important trade-offs.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Radiology and Neuroradiology, Evangelisches Krankenhaus Oldenburg, Steinweg 13-17, 26122 Oldenburg, Niedersachsen, Germany"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "C. G. Iacoban"
    },
    {
      "name": "H. Bösenberg"
    },
    {
      "name": "C. Klüner"
    },
    {
      "name": "O. Alykova"
    },
    {
      "name": "M. Gerdes"
    },
    {
      "name": "F. Meinert"
    },
    {
      "name": "B. Sundermann"
    },
    {
      "name": "C. Mathys"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cnennp9ct7km5.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.11.02.26367077",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.11.02.26367077v1.full",
  "id": "cnennp9ct7km5",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.11.02.26367077v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "radiology and imaging"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.11.02.26367077v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-02",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cnennp9ct7km5.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T00:21:04Z",
      "native_id": "10.64898/2026.11.02.26367077",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.11.02.26367077v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:radiology and imaging",
      "subfield": "imaging"
    }
  ],
  "title": "PROSPECTIVE COMPARISON OF OPTIMIZED COMPRESSED SENSING AND GRAPPA-ACCELERATED 3D-TOF-MRA FOR EVALUATION OF UNTREATED INTRACRANIAL ANEURYSMS AT 1.5 T: A NON-INFERIORITY STUDY",
  "title_text": "PROSPECTIVE COMPARISON OF OPTIMIZED COMPRESSED SENSING AND GRAPPA-ACCELERATED 3D-TOF-MRA FOR EVALUATION OF UNTREATED INTRACRANIAL ANEURYSMS AT 1.5 T: A NON-INFERIORITY STUDY",
  "type": "preprint",
  "updated_at": "2026-11-05T00:20:36Z",
  "url": "https://research.draconitic.com/paper/cnennp9ct7km5",
  "venue": "medRxiv",
  "versions": []
}