{
  "abstract": "Background/Objectives: Alcohol-related acute-on-chronic liver failure (ACLF) carries high early mortality, but prognostic evidence varies by definition, endpoint, and adjustment. We estimated short-term mortality and synthesized clinically useful predictors. Methods: PubMed/MEDLINE, Scopus, and Web of Science were searched to 25 June 2026 and, with a revised strategy, to 28 September 2026. Direct alcohol-related ACLF cohorts formed the core evidence base. Mortality was pooled using REML random-effects models with Hartung-Knapp confidence intervals and 95% prediction intervals (PIs); predictors were synthesized qualitatively. Risk of bias and certainty were assessed with QUIPS and GRADE. Results: Forty reports (35 independent cohorts) were included. Pooled mortality was 36.0% at 28/30 days (11 cohorts; 95% CI 28.9-43.8; PI 17.3-60.3%) and 50.2% at 90 days (11 cohorts; 95% CI 39.5-60.8; PI 19.2-81.0%), without significant differences between APASL/AARC- and EASL-CLIF-defined cohorts. Qualitatively, organ-failure burden, infection or sepsis, hepatic encephalopathy, renal dysfunction, shock, and higher MELD-, CLIF-, or AARC-based severity were the most consistent adverse signals; pooled predictor effects could not be estimated. Conclusions: About one-third of patients die by 28/30 days and half by 90 days, but mortality varies widely across settings. Predominantly very low-certainty predictor evidence supports framework-appropriate scores and repeated assessment rather than a universal cutoff.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Internal Diseases, Astana Medical University, Astana 010000, Kazakhstan.",
    "Department of Pediatric Diseases, Astana Medical University, Astana 010000, Kazakhstan.",
    "Department of Natural Sciences, West Kazakhstan Marat Ospanov Medical University, Aktobe 030019, Kazakhstan."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ayauzhan A Sapanova",
      "orcid": "0009-0004-8643-5546"
    },
    {
      "affs": [
        0
      ],
      "name": "Venera S Rakhmetova"
    },
    {
      "affs": [
        1
      ],
      "name": "Assylzhan M Messova"
    },
    {
      "affs": [
        2
      ],
      "name": "Amin Tamadon",
      "orcid": "0000-0002-0222-3035"
    },
    {
      "affs": [
        1
      ],
      "name": "Sagira T Abdrakhmanova"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cnqqdz72h2eyq.bib",
  "cited_by": 0,
  "doi": "10.3390/healthcare14203543",
  "fulltext_url": "https://europepmc.org/articles/PMC13704466",
  "id": "cnqqdz72h2eyq",
  "issns": [
    "2227-9032"
  ],
  "landing_url": "https://europepmc.org/article/MED/42940592",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2721|Liver Disease and Transplantation"
    ]
  ],
  "openalex": "W7223123019",
  "pdf_url": "https://europepmc.org/articles/PMC13704466?pdf=render",
  "pmcid": "PMC13704466",
  "pmid": "42940592",
  "published": "2026-10-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cnqqdz72h2eyq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:12Z",
      "native_id": "MED:42940592",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42940592"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2721|Liver Disease and Transplantation",
      "subfield": "general"
    }
  ],
  "title": "Short-Term Mortality and Its Predictors in Alcohol-Related Acute-on-Chronic Liver Failure: A Systematic Review and Meta-Analysis.",
  "title_text": "Short-Term Mortality and Its Predictors in Alcohol-Related Acute-on-Chronic Liver Failure: A Systematic Review and Meta-Analysis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:12Z",
  "url": "https://research.draconitic.com/paper/cnqqdz72h2eyq",
  "venue": "Healthcare (Basel, Switzerland)",
  "versions": []
}