{
  "abstract": "Non-alcoholic fatty liver disease (NAFLD) is the liver manifestation of the metabolic syndrome with global prevalence reaching epidemic levels. Despite the high disease burden in the population only a small proportion of those with NAFLD will develop progressive liver disease, for which there is currently no approved pharmacotherapy. Identifying those who are at risk of progressive NAFLD currently requires a liver biopsy which is problematic. Firstly, liver biopsy is invasive and therefore not appropriate for use in a condition like NAFLD that affects a large proportion of the population. Secondly, biopsy is limited by sampling and observer dependent variability which can lead to misclassification of disease severity. Non-invasive biomarkers are therefore needed to replace liver biopsy in the assessment of NAFLD. Our study addresses this unmet need. The LITMUS Imaging Study is a prospectively recruited multi-centre cohort study evaluating magnetic resonance imaging and elastography, and ultrasound elastography against liver histology as the reference standard. Imaging biomarkers and biopsy are acquired within a 100-day window. The study employs standardised processes for imaging data collection and analysis as well as a real time central monitoring and quality control process for all the data submitted for analysis. It is anticipated that the high-quality data generated from this study will underpin changes in clinical practice for the benefit of people with NAFLD. Study Registration: clinicaltrials.gov: NCT05479721.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 52,
  "authors": [
    {
      "name": "Michael Pavlides"
    },
    {
      "name": "Ferenc Mózes"
    },
    {
      "name": "Salma Akhtar"
    },
    {
      "name": "Kristy Wonders"
    },
    {
      "name": "Jeremy Cobbold"
    },
    {
      "name": "Elizabeth Tunnicliffe"
    },
    {
      "name": "Michael Allison"
    },
    {
      "name": "Edmund Godfrey"
    },
    {
      "name": "Guruprasad Aithal"
    },
    {
      "name": "Susan Francis"
    },
    {
      "name": "Manuel Romero-Gomez"
    },
    {
      "name": "Javier Castell"
    },
    {
      "name": "Isabel Fernandez-Lizaranzu"
    },
    {
      "name": "Rocio Aller"
    },
    {
      "name": "Rebeca Sigüenza González"
    },
    {
      "name": "Salvador Agustin"
    },
    {
      "name": "Juan Pericàs"
    },
    {
      "name": "Jerome Boursier"
    },
    {
      "name": "Christophe Aube"
    },
    {
      "name": "Vlad Ratziu"
    },
    {
      "name": "Mathilde Wagner"
    },
    {
      "name": "Salvatore Petta"
    },
    {
      "name": "Michela Antonucci"
    },
    {
      "name": "Elisabetta Bugianesi"
    },
    {
      "name": "Riccardo Faletti"
    },
    {
      "name": "Luca Miele"
    },
    {
      "name": "Andreas Geier"
    },
    {
      "name": "Jörn Schattenberg"
    },
    {
      "name": "Emrich Tilman"
    },
    {
      "name": "Mattias Ekstedt"
    },
    {
      "name": "Peter Lundberg"
    },
    {
      "name": "Annalisa Berzigotti"
    },
    {
      "name": "Adrian Huber"
    },
    {
      "name": "George Papatheodoridis"
    },
    {
      "name": "Hannele Yki-Järvinen"
    },
    {
      "name": "Kimmo Porthan"
    },
    {
      "name": "Moritz Jörg Schneider"
    },
    {
      "name": "Paul Hockings"
    },
    {
      "name": "Elizabeth Shumbayawonda"
    },
    {
      "name": "Rajarshi Banerjee"
    },
    {
      "name": "Kay Pepin"
    },
    {
      "name": "Mike Kalutkiewicz"
    },
    {
      "name": "Richard Ehman"
    },
    {
      "name": "Aldo Trylesinksi"
    },
    {
      "name": "Harvey Coxson"
    },
    {
      "name": "Miljen Martic"
    },
    {
      "name": "Carla Yunis"
    },
    {
      "name": "Theresa Tuthill"
    },
    {
      "name": "Patrick Bossuyt"
    },
    {
      "name": "Quentin Anstee"
    },
    {
      "name": "Stefan Neubauer"
    },
    {
      "name": "Stephen Harrison"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cpe1wpxr3msfj.bib",
  "cited_by": 15,
  "doi": "10.1016/j.cct.2023.107352",
  "fulltext_url": null,
  "id": "cpe1wpxr3msfj",
  "issns": [
    "1551-7144"
  ],
  "landing_url": "https://hal.science/hal-05840404v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
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      "openalex",
      "2713|Liver Disease Diagnosis and Treatment"
    ]
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  "openalex": "W4387339830",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-27",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/cpe1wpxr3msfj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:02Z",
      "native_id": "hal-05840404",
      "source": "hal",
      "url": "https://hal.science/hal-05840404v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Liver Disease Diagnosis and Treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Liver Investigation: Testing Marker Utility in Steatohepatitis (LITMUS): Assessment & validation of imaging modality performance across the NAFLD spectrum in a prospectively recruited cohort study (the LITMUS imaging study): Study protocol",
  "title_text": "Liver Investigation: Testing Marker Utility in Steatohepatitis (LITMUS): Assessment & validation of imaging modality performance across the NAFLD spectrum in a prospectively recruited cohort study (the LITMUS imaging study): Study protocol",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:02Z",
  "url": "https://research.draconitic.com/paper/cpe1wpxr3msfj",
  "venue": "Contemporary Clinical Trials",
  "versions": []
}