{
  "abstract": "Because a given protein may adopt different amyloid protofilament folds, it has become necessary to compare pairs of amyloid structures of a given protein. This article describes the amyloid packing difference (APD), which quantifies the difference between amyloid structures as the percentage of residues involved in unique cross-β packing interactions or side-chain orientations. Clustering of α-synuclein folds on APD values recapitulates clustering based on structural superpositions. Known protofilament folds of the prion protein, tau, α-synuclein, TDP-43, or TAF15 from different neurodegenerative diseases have APD values above 20%, whereas structures that have been associated with the same disease have APD values below 40%. Different individuals with peripheral amyloidosis have antibody light-chain structures with APDs above 60%, whereas transthyretin filaments are strikingly similar, with APDs below 25%. These observations provide context for the interpretation of APD values in future structure comparisons.",
  "abstract_shown": true,
  "affiliations": [
    "Medical Research Council Laboratory of Molecular Biology, CB2 0QH Cambridge, UK. Electronic address: scheres@mrclmb.ac.uk"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sjors H. W. Scheres",
      "orcid": "0000-0002-0462-6540"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cpqwnac5kh6f9.bib",
  "cited_by": 9,
  "doi": "10.1016/j.str.2026.04.014",
  "fulltext_url": null,
  "id": "cpqwnac5kh6f9",
  "issns": [
    "0969-2126",
    "1878-4186"
  ],
  "landing_url": "https://doi.org/10.1016/j.str.2026.04.014",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Alzheimer's disease research and treatments"
    ],
    [
      "openalex",
      "2804|Alzheimer's disease research and treatments"
    ]
  ],
  "openalex": "W7162127483",
  "pdf_url": null,
  "pmcid": "PMC7619344",
  "pmid": "42173092",
  "published": "2026-05-22",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/cpqwnac5kh6f9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:56Z",
      "native_id": "W7162127483",
      "source": "openalex",
      "url": "https://doi.org/10.1016/j.str.2026.04.014"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2804|Alzheimer's disease research and treatments",
      "subfield": "neuroscience"
    },
    {
      "field": "medicine",
      "origin": "openalex:2737|Alzheimer's disease research and treatments",
      "subfield": "physiology"
    }
  ],
  "title": "The amyloid packing difference: A pairwise comparison metric for amyloid structures",
  "title_text": "The amyloid packing difference: A pairwise comparison metric for amyloid structures",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:12Z",
  "url": "https://research.draconitic.com/paper/cpqwnac5kh6f9",
  "venue": "Structure",
  "versions": []
}