{
  "abstract": "Senile osteoporosis (SOP) is an age-related metabolic bone disease characterized by reduced bone quality and increased fracture risk, closely associated with immune senescence. Among immune components in the bone marrow niche, macrophages undergo age-associated phenotypic and functional changes that may impair bone homeostasis; however, whether these changes reflect bona fide senescence, inflammatory activation, or polarization remains unclear. This review summarizes the biological characteristics of senescent macrophages, including alterations in senescence markers, senescence-associated secretory phenotype (SASP), epigenetic modifications, and telomere dynamics. It then outlines their functional changes, focusing on oxidative stress, autophagy, and metabolic dysregulation. Importantly, we discuss how senescent or senescence-like macrophage states may regulate macrophage–bone marrow mesenchymal stem cell (BMSC) crosstalk through SASP-related factors, the grancalcin–plexin-B2 axis, mitochondrial transfer, exosome-mediated signaling, and metabolic reprogramming, while distinguishing direct ageing-related evidence from indirect mechanistic evidence.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Laboratory Medicine, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine/Zhangjiagang Traditional Chinese Medicine Hospital, Zhangjiagang, Jiangsu 215699 China",
    "Laboratory of New Techniques of Restoration & Reconstruction of Orthopedics and Traumatology, Nanjing University of Chinese Medicine, Nanjing, 210023 Jiangsu China",
    "School of Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023 China",
    "Department of Trauma and Orthopedics, Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine, Wuxi, Jiangsu 214071 China",
    "Yancheng TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu 224000 China",
    "TCM Nursing Intervention Key Laboratory of Chronic Disease, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023 China",
    "Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023 China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Qinfeng Zhou"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Kaixuan Wang"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Xiaoxian Sun"
    },
    {
      "affs": [
        1,
        4
      ],
      "name": "Jingyue Fu"
    },
    {
      "affs": [
        0
      ],
      "name": "Lei Wang"
    },
    {
      "affs": [
        5
      ],
      "name": "Qing Wang"
    },
    {
      "affs": [
        1,
        2,
        4
      ],
      "name": "Yong Ma"
    },
    {
      "affs": [
        1,
        6
      ],
      "name": "Yang Guo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cqfnsc9z3dzda.bib",
  "cited_by": 0,
  "doi": "10.1186/s12979-026-00586-4",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13715214/",
  "id": "cqfnsc9z3dzda",
  "issns": [
    "1742-4933"
  ],
  "landing_url": "https://doi.org/10.1186/s12979-026-00586-4",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2737|Telomeres, Telomerase, and Senescence"
    ]
  ],
  "openalex": "W7171842044",
  "pdf_url": null,
  "pmcid": "PMC13715214",
  "pmid": "42947217",
  "published": "2026-07-31",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/cqfnsc9z3dzda.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:22:34Z",
      "native_id": "PMC13715214",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12979-026-00586-4"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Telomeres, Telomerase, and Senescence",
      "subfield": "physiology"
    }
  ],
  "title": "Macrophage senescence and senescence-like states in senile osteoporosis: cellular cross-talk and therapeutic perspectives",
  "title_text": "Macrophage senescence and senescence-like states in senile osteoporosis: cellular cross-talk and therapeutic perspectives",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:34Z",
  "url": "https://research.draconitic.com/paper/cqfnsc9z3dzda",
  "venue": "Immunity & Ageing : I & A",
  "versions": []
}