{
  "abstract": "Persistent inflammatory responses and adverse ventricular remodeling following Acute Myocardial Infarction (MI) are critical factors driving the progressive decline of cardiac function. Traditional pharmacological strategies struggle to achieve effective long-term intervention at the level of tissue repair. The Corydalis yanhusuo ethanolic extract (CYEE) possesses demonstrated anti-inflammatory and antioxidant activities; however, its limited in vivo half-life and the difficulty in maintaining local effective concentrations hinder its efficacy. Concurrently, while mesenchymal stem cells (MSCs) exert therapeutic potential through paracrine and immunomodulatory mechanisms, their low viability within the intensely inflammatory microenvironment of the infarcted myocardium significantly restricts their clinical impact. In this study, a sodium alginate microsphere delivery system was developed using gas-assisted microfluidic technology to achieve the synergistic encapsulation and localized delivery of CYEE and MSCs. This oil-free and surfactant-free microsphere system exhibits excellent biocompatibility, enabling the sustained release of CYEE within the infarcted region to alleviate inflammation and oxidative stress for initial therapeutic intervention. Furthermore, it enhances MSCs viability and paracrine function by optimizing the local microenvironment. In vitro experiments demonstrated that the system significantly improved cell viability under inflammatory conditions and promoted migration and angiogenic capacity. In a rat MI model, synergistic delivery significantly improved cardiac function and attenuated myocardial fibrosis and adverse remodeling without evident systemic toxicity. These results indicate that combining CYEE-mediated microenvironmental regulation with the dynamic synergistic repair of MSCs provides a comprehensive therapeutic strategy with potential translational value for myocardial repair following infarction.",
  "abstract_shown": true,
  "affiliations": [
    "Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology, The NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, China.",
    "Phase I Clinical Trial Center, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511400, China.",
    "Department of Pharmacy, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, 510645, China.",
    "Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology, The NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, China. guoshengtang@gzhmu.edu.cn.",
    "Department of Cardiology, The First Affiliated Hospital of Guangzhou Medical University, China State Key Laboratory for Respiratory Disease, Guangzhou, 510120, China. chenailan1997@gzhmu.edu.cn.",
    "Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology, The NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, China. y3qgz10lhh@icloud.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yuanye Dang"
    },
    {
      "affs": [
        0
      ],
      "name": "Junjie Cai"
    },
    {
      "affs": [
        0
      ],
      "name": "Yongxian Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Xudong Qin"
    },
    {
      "affs": [
        0
      ],
      "name": "Jun Shen"
    },
    {
      "affs": [
        1
      ],
      "name": "Lian Duan"
    },
    {
      "affs": [
        0
      ],
      "name": "Qingyun Lu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyue Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenqi Xiao"
    },
    {
      "affs": [
        2
      ],
      "name": "Ruoxuan Liu"
    },
    {
      "affs": [
        3
      ],
      "name": "Guosheng Tang"
    },
    {
      "affs": [
        4
      ],
      "name": "Ailan Chen"
    },
    {
      "affs": [
        5
      ],
      "name": "Huaibin Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cqwa3c2bftsj7.bib",
  "cited_by": 0,
  "doi": "10.1186/s13020-026-01557-z",
  "fulltext_url": "https://europepmc.org/articles/PMC13721202",
  "id": "cqwa3c2bftsj7",
  "issns": [
    "1749-8546"
  ],
  "landing_url": "https://europepmc.org/article/MED/42963558",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2716|Mesenchymal stem cell research"
    ]
  ],
  "openalex": "W7224810582",
  "pdf_url": "https://europepmc.org/articles/PMC13721202?pdf=render",
  "pmcid": "PMC13721202",
  "pmid": "42963558",
  "published": "2026-10-30",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/cqwa3c2bftsj7.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T03:21:21Z",
      "native_id": "MED:42963558",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42963558"
    },
    {
      "first_seen": "2026-11-03T12:21:56Z",
      "native_id": "PMC13721202",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s13020-026-01557-z"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Mesenchymal stem cell research",
      "subfield": "human-genetics"
    }
  ],
  "title": "Treatment of myocardial infarction via sodium alginate microsphere-mediated co-delivery of Corydalis yanhusuo ethanolic extract and mesenchymal stem cells.",
  "title_text": "Treatment of myocardial infarction via sodium alginate microsphere-mediated co-delivery of Corydalis yanhusuo ethanolic extract and mesenchymal stem cells.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:56Z",
  "url": "https://research.draconitic.com/paper/cqwa3c2bftsj7",
  "venue": "Chinese medicine",
  "versions": []
}