{
  "abstract": "Employing Morita-Baylis-Hillman derived trisubstituted allyl aryl sulfoxides for a one-step dual vicinal functionalisation of indoles for the first time towards the synthesis of 3-aryl-thio-2-allyl indoles. The reaction proceeds via sulfoxide activation, nucleophilic attack of indole and a charge-accelerated [3,3]sigmatropic rearrangement. Selected compounds from the synthesized library showed significant anticancer activity against MDA-MB-7 cell lines with low toxicity towards normal MCF-10A cell line highlighting their potential as anticancer agents.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry",
    "National Institute of Technology",
    "Central University of Tamil Nadu",
    "Department of Chemical Engineering",
    "Birla Institute of Technology and Science",
    "Instituto de Ciencias Aplicadas, Universidad Autónoma de Chile, Del Valle 534, Huechuraba, Santiago, Chile",
    "Faculty of Medicine, University of Atacama, Los Carreras 1579, Copiapó, Chile, 1532502"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Aishwarya Subramanian"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Trinadh Ballanki"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Siddireddi Kalyanram"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Vaishnu Suresh Kumar"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Mohit Garg"
    },
    {
      "affs": [
        5
      ],
      "name": "Diego Quezada"
    },
    {
      "affs": [
        6
      ],
      "name": "Jebiti Haribabu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Baby Viswambharan",
      "orcid": "0000-0003-4270-1510"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cqzxf053md1wa.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15009042/v1",
  "fulltext_url": null,
  "id": "cqzxf053md1wa",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009042/v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Sulfur-Based Synthesis Techniques"
    ]
  ],
  "openalex": "W7213559589",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009042/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-18",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/cqzxf053md1wa.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:19Z",
      "native_id": "10.26434/chemrxiv.15009042",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009042/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Sulfur-Based Synthesis Techniques",
      "subfield": "organic"
    }
  ],
  "title": "Morita-Baylis-Hillman Allyl-Aryl Sulfoxides for the Dual Functionalization of Indoles via Interrupted Pummerer Rearrangement: Unlocking its Anticancer Potential",
  "title_text": "Morita-Baylis-Hillman Allyl-Aryl Sulfoxides for the Dual Functionalization of Indoles via Interrupted Pummerer Rearrangement: Unlocking its Anticancer Potential",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:19Z",
  "url": "https://research.draconitic.com/paper/cqzxf053md1wa",
  "venue": "ChemRxiv",
  "versions": []
}