{
  "abstract": "Mechanosensitive ion transport plays a central role in enabling living systems to perceive and adapt to their environment through the deformation of soft, embedded ion channels. In this work, we demonstrate that ion transport within a two-dimensional graphite nanoslit can be rationally engineered to achieve a bipolar, pressure-sensitive response without any structural deformation. The mechanosensitivity arises from the selective charging of one channel inlet, which acts as a reversible source of mobile charge carriers. These excess ions can then be advected in or out of the channel by the pressure-driven water flow, thereby modulating the ionic conductance. This mechanism is captured through a comprehensive electrohydrodynamic model that analytically accounts for coupled diffusion, convection, surface transport, diffusio-osmosis, and interfacial slippage, both inside and outside the nanoslit. The theoretical framework quantitatively reproduces the experimental data, showing that a simple surface charge pattern can give rise to complex, pressure-dependent conductance. These findings reveal how rich nonlinear couplings at the nanoscale can be harnessed to design adaptive, bioinspired nanofluidic systems, exemplified here by ionic pressure sensors.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Mathieu Lizée"
    },
    {
      "name": "Zhijia Zhang"
    },
    {
      "name": "Baptiste Coquinot"
    },
    {
      "name": "Qian Yang"
    },
    {
      "name": "Lydéric Bocquet"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/crj6dx941pq5f.bib",
  "cited_by": 1,
  "doi": "10.1126/sciadv.aed4451",
  "fulltext_url": null,
  "id": "crj6dx941pq5f",
  "issns": [
    "2375-2548"
  ],
  "landing_url": "https://hal.science/hal-05767031v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "2204|Nanopore and Nanochannel Transport Studies"
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  "openalex": "W7171660540",
  "pdf_url": "https://hal.science/hal-05767031/document",
  "pmcid": null,
  "pmid": "42525771",
  "published": "2026-09-28",
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "ris": "https://research.draconitic.com/paper/crj6dx941pq5f.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:42Z",
      "native_id": "hal-05767031",
      "source": "hal",
      "url": "https://hal.science/hal-05767031v1"
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  "subjects": [
    {
      "field": "physics",
      "origin": "hal:2.phys.phys.phys-bio-ph",
      "subfield": "biological-medical"
    },
    {
      "field": "physics",
      "origin": "hal:2.phys.meca.mefl",
      "subfield": "fluid-dynamics"
    }
  ],
  "title": "Architecting mechanosensitive nanofluidic transport in graphite nanoslits",
  "title_text": "Architecting mechanosensitive nanofluidic transport in graphite nanoslits",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:42Z",
  "url": "https://research.draconitic.com/paper/crj6dx941pq5f",
  "venue": "Science Advances",
  "versions": []
}