{
  "abstract": "Background/Objectives: To compare the postoperative analgesic efficacy of the serratus posterior superior intercostal plane (SPSIP) block and pectoral nerve block II (PECS II) in patients undergoing unilateral modified radical mastectomy (MRM). Methods: This single-center retrospective cohort study included 100 patients who underwent unilateral MRM and received either an SPSIP block (n = 34) or a PECS II block (n = 66). The primary outcome was the time from extubation to the first administration of rescue analgesia. Secondary outcomes included Numeric Rating Scale (NRS) pain scores at 1, 4, 8, and 12 h postoperatively, the maximum NRS pain score, and cumulative opioid consumption within the first 24 postoperative hours. The primary outcome was analyzed using a generalized linear model with a gamma distribution and log-link function adjusted for operative duration. A sensitivity analysis additionally adjusted for age, body mass index, American Society of Anesthesiologists (ASA) physical status, and smoking status. Results: Among 100 patients (SPSIP, n = 34; PECS II, n = 66), operative duration was longer in the PECS II group (p < 0.001). Time to first rescue analgesia was longer with SPSIP (7.5 [5.0–8.8] vs. 5.0 [3.0–8.0] h; p = 0.004), but the difference was not significant after adjustment for operative duration (exp(B) = 1.21, 95% CI 0.98–1.49; p = 0.077) or additional covariates (exp(B) = 1.17, 95% CI 0.94–1.46; p = 0.153). NRS scores were lower with SPSIP at 1 h (p < 0.001) and with PECS II at 8 and 12 h (Holm-adjusted p = 0.013 and p < 0.001). Twenty-four-hour tramadol consumption was similar (p = 0.922). No block-related complications were documented. Conclusions: After adjustment for operative duration, the longer time to first rescue analgesia observed in the SPSIP group did not retain statistical significance, and a similar result was obtained in the sensitivity analysis. The findings should be interpreted cautiously in view of the retrospective design and limited sample size.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anesthesiology and Reanimation, İzmir City Hospital, 35540 Izmir, Türkiye",
    "Department of Anesthesiology and Reanimation, İzmir Faculty of Medicine, University of Health Sciences, 35540 Izmir, Türkiye",
    "Department of Anesthesiology and Reanimation, Izmir Bazekol Çiğli Hospital, 35630 Izmir, Türkiye",
    "Department of General Surgery, İzmir Faculty of Medicine, University of Health Sciences, 35540 Izmir, Türkiye"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hilal Hande Başaran",
      "orcid": "0009-0003-1094-5825"
    },
    {
      "affs": [
        0
      ],
      "name": "Canan Salman Önemli",
      "orcid": "0000-0002-6789-2096"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Derya Arslan Yurtlu",
      "orcid": "0000-0002-7250-1256"
    },
    {
      "affs": [
        0
      ],
      "name": "Pelin Uzun Sarıtaş"
    },
    {
      "affs": [
        2
      ],
      "name": "Zeki Tuncel Tekgül",
      "orcid": "0000-0002-2728-8185"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Cem Karaali"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/crka1w9mk184j.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15218757",
  "fulltext_url": null,
  "id": "crka1w9mk184j",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/21/8757",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-09",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/crka1w9mk184j.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T00:21:41Z",
      "native_id": "10.3390/jcm15218757",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/21/8757"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Comparison of Serratus Posterior Superior Intercostal Plane Block and Pectoral Nerve Block II for Postoperative Analgesia Following Modified Radical Mastectomy: A Retrospective Cohort Study",
  "title_text": "Comparison of Serratus Posterior Superior Intercostal Plane Block and Pectoral Nerve Block II for Postoperative Analgesia Following Modified Radical Mastectomy: A Retrospective Cohort Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T00:21:41Z",
  "url": "https://research.draconitic.com/paper/crka1w9mk184j",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}