{
  "abstract": "Background/objectives\n\nPandemic non-pharmaceutical interventions virtually eliminated respiratory syncytial virus (RSV) circulation in 2020-2021, and their relaxation was followed by unprecedented off-season resurgences. This narrative review, informed by a structured literature search, synthesizes current evidence on healthcare-associated RSV (HA-RSV), including transmission dynamics, vulnerable inpatient populations, and integrated prevention strategies, in the post-pandemic era.Methods\n\nWe searched PubMed/MEDLINE and Europe PMC (January 2000-October 2025) using two complementary strategies, supplemented by WHO and CDC guidance. Primary hospital-based studies reporting laboratory-confirmed HA-RSV cases formed the core evidence set; surveillance reports, systematic reviews, and guidance were used as labeled contextual evidence and synthesized narratively.Results\n\nTwenty-nine primary studies from neonatal, pediatric, adult, geriatric, and immunocompromised settings provided direct evidence on HA-RSV, which accounted for 3-15% of RSV hospitalizations depending on setting and case definition and was associated with prolonged stay, escalation of respiratory support, higher costs, and, in children, higher mortality than community-onset infection. Universal masking and pre-admission screening were followed by reductions in HA-RSV in most before-after studies. Post-pandemic surveillance shows earlier, less predictable RSV activity and periods of concurrent circulation with influenza and SARS-CoV-2. RSV spreads mainly through short-range respiratory particles and contaminated hands and surfaces; asymptomatic or mildly symptomatic healthcare workers are one potential source of introduction.Conclusions\n\nPrevention of HA-RSV rests on hand hygiene, transmission-based precautions, environmental disinfection, rapid molecular diagnostics, and supportive healthcare-worker and visitor policies, escalated according to local surveillance rather than the calendar. Immunoprophylaxis and vaccination reduce severe RSV disease in eligible groups, but direct evidence that they prevent healthcare-associated transmission is lacking.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Infectious Diseases, Department of Internal Medicine, Taichung Veterans General Hospital, 1650 Taiwan Boulevard, Section 4, Taichung 407219, Taiwan.",
    "Infection Control Center, Taichung Veterans General Hospital, 1650 Taiwan Boulevard, Section 4, Taichung 407219, Taiwan.",
    "Genomic Center for Infectious Diseases, Taichung Veterans General Hospital, 1650 Taiwan Boulevard, Section 4, Taichung 407219, Taiwan.",
    "School of Medicine, National Yang Ming Chiao Tung University, No. 155, Section 2, Linong Street, Beitou District, Taipei 112304, Taiwan.",
    "Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, 145 Xingda Road, South District, Taichung 402202, Taiwan.",
    "Doctoral Program in Translational Medicine, Rong Hsing Translational Medicine Research Center, National Chung Hsing University, 145 Xingda Road, South District, Taichung 402202, Taiwan.",
    "Institute of Clinical Medicine, National Yang Ming Chiao Tung University, No. 155, Section 2, Linong Street, Beitou District, Taipei 112304, Taiwan."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Po-Hsiu Huang",
      "orcid": "0009-0003-0952-5057"
    },
    {
      "affs": [
        1
      ],
      "name": "Pei-Hsuan Huang"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4,
        5
      ],
      "name": "Po-Yu Liu",
      "orcid": "0000-0001-8006-4917"
    },
    {
      "affs": [
        0,
        2,
        6
      ],
      "name": "Ting-Kuang Yeh",
      "orcid": "0000-0001-5540-4780"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/crrnqyrcy03y7.bib",
  "cited_by": 0,
  "doi": "10.3390/healthcare14193335",
  "fulltext_url": "https://europepmc.org/articles/PMC13665019",
  "id": "crrnqyrcy03y7",
  "issns": [
    "2227-9032"
  ],
  "landing_url": "https://europepmc.org/article/MED/42881774",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Respiratory viral infections research"
    ]
  ],
  "openalex": "W7220748179",
  "pdf_url": "https://europepmc.org/articles/PMC13665019?pdf=render",
  "pmcid": "PMC13665019",
  "pmid": "42881774",
  "published": "2026-10-06",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/crrnqyrcy03y7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42881774",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42881774"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Respiratory viral infections research",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Nosocomial Respiratory Syncytial Virus in the Post-Pandemic Era: Evolving Epidemiology and Integrated Prevention Strategies.",
  "title_text": "Nosocomial Respiratory Syncytial Virus in the Post-Pandemic Era: Evolving Epidemiology and Integrated Prevention Strategies.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/crrnqyrcy03y7",
  "venue": "Healthcare (Basel, Switzerland)",
  "versions": []
}