{
  "abstract": "A 49-year-old man developed therapy-related acute myeloid leukemia (t-AML) nine years after undergoing treatment for acute promyelocytic leukemia. A genetic analysis revealed a TP53 mutation and a complex karyotype featuring der(5;17)(p10;q10) translocation. This combination is associated with an extremely poor prognosis and chemoresistance. However, the patient achieved complete remission with CPX-351 (liposomal daunorubicin/cytarabine) and subsequently underwent allogeneic hematopoietic stem cell transplantation. He has remained in remission for over five months after the transplant. CPX-351 followed by early transplantation may be an important therapeutic option for selected high-risk patients, such as those with TP53-mutatied t-AML.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Aya Kamiya"
    },
    {
      "name": "Yoshinori Hashimoto"
    },
    {
      "name": "Hiromi Omura"
    },
    {
      "name": "Takayuki Tanaka"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cs4e18xm8g8bw.bib",
  "cited_by": 0,
  "doi": "10.2169/internalmedicine.7870-26",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7870-26/_article",
  "id": "cs4e18xm8g8bw",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7870-26/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "2720|Acute Myeloid Leukemia Research"
    ]
  ],
  "openalex": "W7201850738",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7870-26/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cs4e18xm8g8bw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "10.2169/internalmedicine.7870-26",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7870-26/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2720|Acute Myeloid Leukemia Research",
      "subfield": "general"
    }
  ],
  "title": "TP53-mutated Therapy-related Leukemia with the Der(5;17)(p10;q10) Chromosomal Abnormality Following Chemotherapy for Acute Promyelocytic Leukemia Bridged to Allogeneic Hematopoietic Stem Cell Transplantation Using CPX-351",
  "title_text": "TP53-mutated Therapy-related Leukemia with the Der(5;17)(p10;q10) Chromosomal Abnormality Following Chemotherapy for Acute Promyelocytic Leukemia Bridged to Allogeneic Hematopoietic Stem Cell Transplantation Using CPX-351",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/cs4e18xm8g8bw",
  "venue": "Internal Medicine",
  "versions": []
}