{
  "abstract": "A substantial gap persists between scientific evidence and clinical practice in heart failure (HF). Digital solutions have emerged as promising strategies to accelerate the implementation of evidence-based therapies. This mini-review examines the results of the EMAIL-HF study, a registry-based, randomized, controlled, parallel-group clinical trial conducted in Denmark that included patients aged 20 years or older with a diagnosis of HF irrespective of left ventricular ejection fraction, who were not receiving SGLT2 inhibitors (SGLT2i). Participants were randomized to usual care or a digital strategy consisting of an e-mailed letter with information on SGLT2i, followed by contact with an HF specialist. The primary endpoint was the proportion of patients redeeming a prescription for dapagliflozin or empagliflozin within 6 months of randomization and the secondary endpoint was a composite of time to first HF hospitalization or death from any cause. The digital strategy significantly increased SGLT2i initiation within 6 months, although no difference in HF hospitalization or all-cause mortality was observed during the 24-month follow-up. Whether these strategies can translate modest improvements in treatment uptake into sustained, scalable, and cost-effective gains across diverse healthcare systems remains uncertain.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "name": "Monica T A Albuquerque"
    },
    {
      "name": "Patricia O Guimaraes"
    },
    {
      "name": "Caio a M Tavares"
    },
    {
      "name": "Vagner Madrini"
    },
    {
      "name": "Eduardo B Martins"
    },
    {
      "name": "Kalliopi Keramida"
    },
    {
      "name": "Dike Ojji"
    },
    {
      "name": "Kaveh Hosseini"
    },
    {
      "name": "Luca Monzo"
    },
    {
      "name": "Francesca Musella"
    },
    {
      "name": "Yasuhiko Sakata"
    },
    {
      "name": "Mario Enrico Canonico"
    },
    {
      "name": "Tamas Alexy"
    },
    {
      "name": "Jan Biegus"
    },
    {
      "name": "Savina Nodari"
    },
    {
      "name": "Andrew Ambrosy"
    },
    {
      "name": "Mitja Lainscak"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cs5d2ng4fpwbd.bib",
  "cited_by": 0,
  "doi": "10.1007/s10741-026-10691-7",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13744542/",
  "id": "cs5d2ng4fpwbd",
  "issns": [
    "1382-4147",
    "1573-7322"
  ],
  "landing_url": "https://hal.univ-lorraine.fr/hal-05857836v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "heading",
      "Mini Review"
    ],
    [
      "openalex",
      "2705|Heart Failure Treatment and Management"
    ]
  ],
  "openalex": "W7225461010",
  "pdf_url": "https://hal.univ-lorraine.fr/hal-05857836/document",
  "pmcid": "PMC13744542",
  "pmid": "42998105",
  "published": "2026-11-07",
  "publisher": "Springer Verlag",
  "ris": "https://research.draconitic.com/paper/cs5d2ng4fpwbd.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T12:20:54Z",
      "native_id": "hal-05857836",
      "source": "hal",
      "url": "https://hal.univ-lorraine.fr/hal-05857836v1"
    },
    {
      "first_seen": "2026-11-11T12:22:04Z",
      "native_id": "PMC13744542",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s10741-026-10691-7"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Heart Failure Treatment and Management",
      "subfield": "cardiovascular"
    }
  ],
  "title": "EMAIL-HF: Can Digital Strategies Shorten the Path from Scientific Evidence to Clinical Practice in Heart Failure?",
  "title_text": "EMAIL-HF: Can Digital Strategies Shorten the Path from Scientific Evidence to Clinical Practice in Heart Failure?",
  "type": "peer-reviewed",
  "updated_at": "2026-11-12T12:21:01Z",
  "url": "https://research.draconitic.com/paper/cs5d2ng4fpwbd",
  "venue": "Heart Failure Reviews",
  "versions": []
}