{
  "abstract": "IκBζ, an atypical IκB protein induced downstream of Toll-like receptor (TLR) signaling, is pivotal in orchestrating inflammatory responses and modulating inflammation-associated B cell malignancies. However, the transcriptional and epigenetic programs regulated by IκBζ in both normal and malignant B cells remain poorly described. Here, we analyzed chronic lymphocytic leukemia (CLL) cells by epigenomic profiling to dissect the molecular function of IκBζ in leukemia. In primary human B cells and CLL samples, chromatin immunoprecipitation sequencing (ChIP-seq) and cleavage under targets and tagmentation (CUT&Tag) analyses delineated a comprehensive genome-wide landscape of IκBζ binding sites. Key genes, including NFKB2, BATF, and FOXP1, gained IκBζ binding after TLR stimulation in both CLL and B cells, whereas CXCR5 was mainly bound in CLL cells. Pharmacological or genetic inhibition of IκBζ signaling disrupted the induction of these molecules, highlighting its potential role as a central transcriptional tuner that integrates TLR-mediated inflammatory pathways with B cell receptor (BCR) signaling and migration.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "name": "Ilenia Sana"
    },
    {
      "name": "Miriam Meloni",
      "orcid": "0009-0000-0837-8946"
    },
    {
      "name": "Francesca Genova",
      "orcid": "0000-0002-7470-6386"
    },
    {
      "name": "Maria Elena Mantione",
      "orcid": "0000-0002-1203-2515"
    },
    {
      "name": "Anna Sofia Tascini"
    },
    {
      "name": "Ettore Zapparoli"
    },
    {
      "name": "Greta Carbone Faccin",
      "orcid": "0009-0009-8758-1445"
    },
    {
      "name": "Dimitra Paschaloudi"
    },
    {
      "name": "Martina Del Nero"
    },
    {
      "name": "Chiara Lenzi"
    },
    {
      "name": "Pamela Ranghetti"
    },
    {
      "name": "Eleonora Perotta"
    },
    {
      "name": "Lydia Scarfò"
    },
    {
      "name": "Paolo Ghia"
    },
    {
      "name": "Marta Muzio",
      "orcid": "0000-0002-7761-759X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/csn9acp2prpds.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.117828",
  "fulltext_url": "https://europepmc.org/articles/PMC13682367",
  "id": "csn9acp2prpds",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03209-8",
  "language": "eng",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Cancer"
    ],
    [
      "heading",
      "Microenvironment"
    ],
    [
      "heading",
      "Molecular mechanism of gene regulation"
    ],
    [
      "heading",
      "Transcriptomics"
    ],
    [
      "openalex",
      "2716|Chronic Lymphocytic Leukemia Research"
    ]
  ],
  "openalex": "W7221574457",
  "pdf_url": "https://europepmc.org/articles/PMC13682367?pdf=render",
  "pmcid": "PMC13682367",
  "pmid": "42903746",
  "published": "2026-10-12",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/csn9acp2prpds.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:16Z",
      "native_id": "10.1016/j.isci.2026.117828",
      "source": "feed-cell",
      "url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03209-8"
    },
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "10.1016/j.isci.2026.117828",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589004226032098"
    },
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42903746",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42903746"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "heading:Cancer",
      "subfield": "oncology"
    }
  ],
  "title": "IκBζ target genes in chronic lymphocytic leukemia",
  "title_text": "IκBζ target genes in chronic lymphocytic leukemia",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/csn9acp2prpds",
  "venue": "iScience",
  "versions": []
}