{
  "abstract": "Background: Trousseau syndrome is a paraneoplastic hypercoagulable state manifesting as recurrent thromboembolism. Lung adenocarcinomas harboring specific driver mutations, such as ROS1 rearrangements, are associated with a significantly increased risk of these events and related complications. Case presentation: A 61-year-old non-smoking female with stage IV ROS1-positive lung adenocarcinoma developed bilateral cerebral and cerebellar infarctions. While aspirin therapy was initiated, she still experienced a recurrent ischemic stroke involving the left middle cerebral artery, leading to a diagnosis of Trousseau syndrome. However, the course was further complicated by pneumonia and respiratory failure. Anticoagulation with apixaban was initiated. A third embolic event subsequently occurred, involving a right middle cerebral artery occlusion with associated subarachnoid hemorrhage and hemorrhagic transformation. Despite intensive management, the patient’s condition deteriorated, and she passed away. Conclusions: Trousseau syndrome significantly impairs the prognosis of lung cancer patients, especially with specific driven genes, such as ROS-1 gene re-arrangement. This case highlights the deteriorating prognosis of cancer-associated thrombosis, which can be refractory and requires heightened clinical vigilance.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City 220216, Taiwan",
    "Department of Chemical Engineering and Materials Science, Yuan-Ze University, Taoyuan City 320315, Taiwan"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Tsung-Ta Wu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Shih-Lung Cheng",
      "orcid": "0000-0003-0111-3157"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/csnjtktkn52y8.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15218743",
  "fulltext_url": null,
  "id": "csnjtktkn52y8",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/21/8743",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-09",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/csnjtktkn52y8.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T00:21:41Z",
      "native_id": "10.3390/jcm15218743",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/21/8743"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Trousseau Syndrome Manifesting as Recurrent Embolic Stroke in ROS1-Positive Non-Small-Cell Lung Cancer: A Case Report",
  "title_text": "Trousseau Syndrome Manifesting as Recurrent Embolic Stroke in ROS1-Positive Non-Small-Cell Lung Cancer: A Case Report",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T00:21:41Z",
  "url": "https://research.draconitic.com/paper/csnjtktkn52y8",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}