{
  "abstract": "Post-dengue fatigue syndrome is a debilitating long-term condition that affects daily activities, quality of life, and productivity. Its underlying mechanisms remain unclear, but clinical similarities with post-dengue depression complicate differentiation. Therefore, we conducted a systematic review and meta-analysis to identify and compare factors associated with post-dengue fatigue and post-dengue depression. We searched PubMed, Science Direct, Web of Science and Google Scholar databases until 6 June 2025, with an update performed on 31 December 2025. This systematic review was conducted according to PRISMA guidelines. Meta-analyses were conducted to assess associations of demographic, biological, clinical, medical or psychosocial factors with post-dengue fatigue and post-dengue depression using pooled odds ratios (OR). The study protocol was registered in PROSPERO (CRD420250655004). Nine studies (2006-2023) covering 1470 patients were included. The systematic review identified 13 factors eligible for meta-analysis: twelve factors for post-dengue fatigue and one for post-dengue depression. Among these factors, female sex (OR 1.69, 95% CI: 1.33-2.14), myalgia (OR 3.45, 95% CI: 2.10-5.69), and severe dengue (OR 4.02, 95% CI: 1.45-11.13), particularly dengue haemorrhagic fever (OR 1.53, 95% CI: 1.04-2.24), were associated with post-dengue fatigue. No factor was associated with post-dengue depression in the meta-analysis. However, narrative synthesis revealed thrombocytopaenia as a shared factor of both outcomes. This study highlights risk profiles for post-dengue fatigue syndrome and depression, with female sex, myalgia, and dengue severity specifically associated with fatigue, while thrombocytopaenia might indicate a shared pathway. These findings support targeted surveillance and management strategies for at-risk patients and highlight the need for further research into post-dengue depression mechanisms.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "Anna Condé"
    },
    {
      "name": "Olivier Maillard"
    },
    {
      "name": "Chaturaka Rodrigo"
    },
    {
      "name": "Antoine Bertolotti"
    },
    {
      "name": "Carolina X Sandler"
    },
    {
      "name": "Andrew R Lloyd"
    },
    {
      "name": "Patrick Gérardin"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/csvqvnb63c1cz.bib",
  "cited_by": 1,
  "doi": "10.1002/rmv.70164",
  "fulltext_url": null,
  "id": "csvqvnb63c1cz",
  "issns": [
    "1052-9276",
    "1099-1654"
  ],
  "landing_url": "https://hal.science/hal-05790977v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2739|Mosquito-borne diseases and control"
    ]
  ],
  "openalex": "W7161827702",
  "pdf_url": "https://hal.science/hal-05790977/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-10",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/csvqvnb63c1cz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:53Z",
      "native_id": "hal-05790977",
      "source": "hal",
      "url": "https://hal.science/hal-05790977v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Mosquito-borne diseases and control",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Post‐Infectious Fatigue and Depression Following Dengue: A Systematic Review and Meta‐Analysis of Associated Factors",
  "title_text": "Post‐Infectious Fatigue and Depression Following Dengue: A Systematic Review and Meta‐Analysis of Associated Factors",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:53Z",
  "url": "https://research.draconitic.com/paper/csvqvnb63c1cz",
  "venue": "Reviews in Medical Virology",
  "versions": []
}