{
  "abstract": "Blood phosphorylated tau 217 (p-tau217) accurately detects Alzheimer’s disease (AD) pathology but is also elevated in amyotrophic lateral sclerosis (ALS), likely reflecting peripheral (big) tau released from muscle. Assays selectively measuring brain-derived (BD-) tau and BD-p-tau217 are therefore needed. We analysed serum BD-tau and p-tau217 in ALS ( n = 139), AD ( n = 101) and controls ( n = 75) using direct immunoassays and after BD-Tau immunoprecipitation (BD-Tau-IP), and tau species in brain ( n = 16), spinal cord ( n = 11) and muscle ( n = 10) by targeted mass spectrometry. With the direct immunoassays, BD-tau and p-tau217 were increased in AD and ALS versus controls. After BD-Tau-IP, BD-tau and BD-p-tau217 were elevated in AD only, improving diagnostic accuracy. Mass spectrometry revealed a central-to-peripheral shift from BD-tau to big tau predominance, with exclusively big p-tau217 detected in muscle. Selective detection of BD-tau species improves the specificity of blood AD biomarkers by reducing peripheral tau confounding.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 27,
  "authors": [
    {
      "name": "Samir Abu-Rumeileh",
      "orcid": "0000-0003-0631-8506"
    },
    {
      "name": "Henning Großkopf",
      "orcid": "0000-0002-5122-2477"
    },
    {
      "name": "Arthur Guthknecht"
    },
    {
      "name": "Alexander Mensch",
      "orcid": "0000-0003-0089-4473"
    },
    {
      "name": "Dirk Osterloh"
    },
    {
      "name": "Antonia Ratti",
      "orcid": "0000-0002-4264-6614"
    },
    {
      "name": "Julian Conrad"
    },
    {
      "name": "Caroline Stapf"
    },
    {
      "name": "Julia Krippner"
    },
    {
      "name": "Patrick Oeckl",
      "orcid": "0000-0002-7652-7023"
    },
    {
      "name": "Gisela Stoltenburg-Didinger"
    },
    {
      "name": "Alessio Maranzano"
    },
    {
      "name": "Petra Steinacker"
    },
    {
      "name": "Christopher M. Weise"
    },
    {
      "name": "Lorenzo Barba"
    },
    {
      "name": "Lucio D’Anna"
    },
    {
      "name": "Hans-Wolfgang Klafki",
      "orcid": "0000-0002-8672-9032"
    },
    {
      "name": "Jens Wiltfang",
      "orcid": "0000-0003-1492-5330"
    },
    {
      "name": "Vincenzo Silani",
      "orcid": "0000-0002-7698-3854"
    },
    {
      "name": "Lutz Froelich",
      "orcid": "0000-0003-1494-0813"
    },
    {
      "name": "Nicola Ticozzi",
      "orcid": "0000-0001-5963-7426"
    },
    {
      "name": "Lucrezia Hausner",
      "orcid": "0000-0001-9009-2356"
    },
    {
      "name": "Dietmar Rudolf Thal",
      "orcid": "0000-0002-1036-1075"
    },
    {
      "name": "Jochen Hans Weishaupt"
    },
    {
      "name": "Ingolf Lachmann"
    },
    {
      "name": "Federico Verde"
    },
    {
      "name": "Markus Otto",
      "orcid": "0000-0003-4273-4267"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ct2rmtf0pfd7w.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-78390-3",
  "fulltext_url": null,
  "id": "ct2rmtf0pfd7w",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-78390-3",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Alzheimer's disease research and treatments"
    ]
  ],
  "openalex": "W7223176302",
  "pdf_url": "https://www.nature.com/articles/s41467-026-78390-3.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-22",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/ct2rmtf0pfd7w.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:39Z",
      "native_id": "10.1038/s41467-026-78390-3",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-78390-3"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Alzheimer's disease research and treatments",
      "subfield": "physiology"
    }
  ],
  "title": "Tau isoform mapping across tissues and biofluids reveals a signature distinguishing Alzheimer’s disease from amyotrophic lateral sclerosis",
  "title_text": "Tau isoform mapping across tissues and biofluids reveals a signature distinguishing Alzheimer’s disease from amyotrophic lateral sclerosis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:39Z",
  "url": "https://research.draconitic.com/paper/ct2rmtf0pfd7w",
  "venue": "Nature Communications",
  "versions": []
}