{
  "abstract": "Background High lipoprotein (a) is a risk factor for the development of cardiovascular disease. Lp(a) lowering medications are under investigation in clinical trials. We aimed to assess sex/gender-specific differences in the distribution of Lp(a) levels in patients undergoing coronary artery bypass grafting (CABG). Methods This is a prospective, cross-sectional observational trial including patients undergoing CABG. Patients were classified into Lp(a) categories (Lp(a) (nmol/l) < 62, > 105; ≥ 150; ≥ 175; ≥ 200). Univariate and multivariate analyses were used to test for sex/gender-specific differences in Lp(a) distribution. Results Out of all 413 patients undergoing CABG between 11/2024 and 02/2026, 300 patients signed informed consent and 404 had available Lp(a) values. Women were significantly older (p < 0.001), more often never smokers (p = 0.001) and more frequently had a positive family history (p = 0.001). Median Lp(a) levels did not significantly differ between male and female patients in all 404 patients with available Lp(a) levels (27.8 (IQR 118) versus 37.4 (IQR 206.4); p = 0.165). Female patients were significantly more often distributed in Lp(a) categories > 105 nmol/l, ≥ 150 nmol/l, ≥ 175 nmol/l and ≥ 200 nmol/l, also after adjustment in multivariate analysis. Conclusion A sex/gender-specific difference in Lp(a) distribution was observed. Female patients were more often distributed in higher Lp(a) categories than men, especially in Lp(a) categories > 105, ≥ 150, ≥ 175 and ≥ 200 nmol/l. If Lp(a) lowering agents prove to be effective in clinical trials and currently investigated Lp(a) thresholds are adopted, female patients undergoing CABG may represent a subgroup more likely meeting future treatment eligibility criteria for Lp(a) lowering therapies. The observed difference in Lp(a) distribution may yield a potential contributor to the consistently reported poorer clinical outcomes in women after CABG and warrants further investigation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiac Surgery, Medical University of Innsbruck, Innsbruck, Austria",
    "Central Institute of Clinical and Chemical Laboratory Diagnostics, University Hospital of Innsbruck, Innsbruck, Austria"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
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        0
      ],
      "name": "Hannes Abfalterer",
      "orcid": "0000-0002-1470-6026"
    },
    {
      "affs": [
        0
      ],
      "name": "Laura Renz"
    },
    {
      "affs": [
        0
      ],
      "name": "Christopher Klingler"
    },
    {
      "affs": [
        0
      ],
      "name": "Lena Gerlach"
    },
    {
      "affs": [
        0
      ],
      "name": "Valentina Corradini"
    },
    {
      "affs": [
        0
      ],
      "name": "Nikolaos Bonaros"
    },
    {
      "affs": [
        0
      ],
      "name": "Michael Grimm"
    },
    {
      "affs": [
        1
      ],
      "name": "Andrea Griesmacher"
    },
    {
      "affs": [
        0
      ],
      "name": "Elfriede Ruttmann-Ulmer"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ct4b4gvccscw1.bib",
  "cited_by": 0,
  "doi": "10.1186/s12944-026-03019-9",
  "fulltext_url": "https://doi.org/10.1186/s12944-026-03019-9",
  "id": "ct4b4gvccscw1",
  "issns": [
    "1476-511X"
  ],
  "landing_url": "https://doi.org/10.1186/s12944-026-03019-9",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "lcc",
      "RC620-627"
    ],
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      "openalex",
      "2705|Lipoproteins and Cardiovascular Health"
    ]
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  "openalex": "W7171960819",
  "pdf_url": null,
  "pmcid": "PMC13741539",
  "pmid": "42989306",
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/ct4b4gvccscw1.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T14:21:02Z",
      "native_id": "011152e9dc87433e9f7e025a28dffbf0",
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      "url": "https://doi.org/10.1186/s12944-026-03019-9"
    },
    {
      "first_seen": "2026-11-10T12:22:34Z",
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Lipoproteins and Cardiovascular Health",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Higher lipoprotein(a) burden in women undergoing coronary artery bypass grafting",
  "title_text": "Higher lipoprotein(a) burden in women undergoing coronary artery bypass grafting",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T14:21:06Z",
  "url": "https://research.draconitic.com/paper/ct4b4gvccscw1",
  "venue": "Lipids in Health and Disease",
  "versions": []
}