{
  "abstract": "Observational studies suggest that maternal diet is associated with birth weight, but the genetic evidence for specific food-related traits and the potential contribution of placental growth remain uncertain. We used bidirectional two-sample Mendelian randomization (MR) to examine 187 food-liking traits and 38 food-consumption traits in relation to 2 continuous birth-weight outcomes. The primary family included 450 forward tests (Bonferroni P < 1.11 × 10−4). Placental-weight, two-step MR, and Bayesian colocalization analyses were interpreted as secondary or exploratory. Roast-chicken, red-meat, lentil/bean, healthy-food, and porridge liking showed suggestive associations with birth weight (P = 4.11 × 10−4 to 1.22 × 10−2), although none met the corrected threshold. Birth weight was a continuous standardized phenotype; therefore, β coefficients are the primary effect estimates. Several placental-weight traits were associated with birth weight in secondary analyses, and the directionally compatible two-step components were consistent with a potential placental pathway. Placental-weight and maternal-effect birth-weight signals colocalized at chromosome 12 (PP.H4 = 0.979) and chromosome 5 (PP.H4 = 0.993). The findings suggest potential relationships among genetically predicted food preference, placental growth, and birth weight. Because the food-related associations did not survive correction and the two-step analyses were conditionally selected, these results are hypothesis-generating rather than proof of causal mediation. The chromosome 12 region containing SLC38A4 remains a biologically plausible candidate for follow-up.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Huan Han",
      "orcid": "0000-0001-8287-3785"
    },
    {
      "affs": [
        0
      ],
      "name": "Hanwen Su"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhihua Lv"
    },
    {
      "affs": [
        0
      ],
      "name": "Chengliang Zhu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jingtao Huang",
      "orcid": "0000-0003-3596-9404"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ct7jdjbrzkzw8.bib",
  "cited_by": 0,
  "doi": "10.1097/md.0000000000051240",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727173/?tool=EBI",
  "id": "ct7jdjbrzkzw8",
  "issns": [
    "0304-5412",
    "1536-5964",
    "0025-7974"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13727173",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "5600"
    ],
    [
      "heading",
      "Observational Study"
    ],
    [
      "heading",
      "Research Article"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727173/pdf/?tool=EBI",
  "pmcid": "PMC13727173",
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "Wolters Kluwer Health",
  "ris": "https://research.draconitic.com/paper/ct7jdjbrzkzw8.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:51Z",
      "native_id": "PMC:PMC13727173",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13727173"
    },
    {
      "first_seen": "2026-11-05T12:23:18Z",
      "native_id": "PMC13727173",
      "source": "pmc",
      "url": "https://doi.org/10.1097/md.0000000000051240"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Genetically predicted food-related traits, placental weight, and birth weight : A Mendelian randomization and colocalization study: impact of diet on birth weight",
  "title_text": "Genetically predicted food-related traits, placental weight, and birth weight : A Mendelian randomization and colocalization study: impact of diet on birth weight",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:54Z",
  "url": "https://research.draconitic.com/paper/ct7jdjbrzkzw8",
  "venue": "Medicine",
  "versions": []
}