{
  "abstract": "Purpose\n\nOlder adults with cardiometabolic diseases (CMDs) often experience medication-related burden (MRB) in the context of long-term use of multiple medications, yet how health literacy and social support relate to this burden remains under-examined. This study aimed to examine the association between health literacy and MRB and the mediating role of perceived social support in this population.Patients and methods\n\nIn this cross-sectional study, 254 community-dwelling older adults (aged ≥65 years) with CMDs using ≥2 prescription medications were recruited from an online survey panel in South Korea between November 14 and 24, 2025. MRB, health literacy, and perceived social support were assessed using the Living with Medicines Questionnaire version 3, Short-Form Health Literacy Instrument, and Multidimensional Scale of Perceived Social Support, respectively. Multiple regression and mediation analysis (SPSS PROCESS macro, Model 4; 5000 bootstrap samples) were performed, adjusting for 10 covariates.Results\n\nParticipants' mean age was 69.83 years (SD = 3.64), and 55.12% were female. Higher health literacy (B = -1.305, p < 0.001), higher perceived social support (B = -0.324, p < 0.001), and good self-rated health (B = -10.162, p < 0.001) were associated with lower MRB (adjusted R ² = 0.394). Social support showed a statistically significant indirect effect in the tested model (indirect effect = -0.243; 95% bootstrap confidence interval [-0.418, -0.098]), accounting for 15.7% of the total effect.Conclusion\n\nHigher health literacy and perceived social support were associated with lower MRB, with social support representing a partial pathway. These findings suggest that efforts to manage MRB may need to prioritize health literacy while also considering supportive social systems. However, given the cross-sectional design and an online panel sample that may underrepresent older adults with limited digital access, frailty, cognitive impairment, or low health literacy, causal inferences cannot be drawn; longitudinal and intervention studies are needed.",
  "abstract_shown": true,
  "affiliations": [
    "College of Nursing, Seoul National University, Seoul, Korea."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jeongyeon Kim",
      "orcid": "0000-0003-1584-5439"
    },
    {
      "affs": [
        0
      ],
      "name": "Kyungmi Woo",
      "orcid": "0000-0002-8710-2696"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ctpsaqt74ry5f.bib",
  "cited_by": 0,
  "doi": "10.2147/ppa.s620656",
  "fulltext_url": "https://europepmc.org/articles/PMC13726597",
  "id": "ctpsaqt74ry5f",
  "issns": [
    "1177-889X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42974465",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2717|Pharmaceutical Practices and Patient Outcomes"
    ]
  ],
  "openalex": "W7224080308",
  "pdf_url": "https://europepmc.org/articles/PMC13726597?pdf=render",
  "pmcid": "PMC13726597",
  "pmid": "42974465",
  "published": "2026-10-29",
  "publisher": "Dove Press",
  "ris": "https://research.draconitic.com/paper/ctpsaqt74ry5f.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:47Z",
      "native_id": "MED:42974465",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42974465"
    },
    {
      "first_seen": "2026-11-05T12:22:54Z",
      "native_id": "PMC13726597",
      "source": "pmc",
      "url": "https://doi.org/10.2147/ppa.s620656"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2717|Pharmaceutical Practices and Patient Outcomes",
      "subfield": "general"
    }
  ],
  "title": "Association Between Health Literacy and Medication-Related Burden in Older Adults with Cardiometabolic Diseases: The Mediating Role of Perceived Social Support in a Cross-Sectional Study.",
  "title_text": "Association Between Health Literacy and Medication-Related Burden in Older Adults with Cardiometabolic Diseases: The Mediating Role of Perceived Social Support in a Cross-Sectional Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:30Z",
  "url": "https://research.draconitic.com/paper/ctpsaqt74ry5f",
  "venue": "Patient preference and adherence",
  "versions": []
}