{
  "abstract": "Cervical cancer remains a predominant malignancy of the female reproductive system and a critical global health challenge. Traditional platinum-based agents such as cisplatin, carboplatin, and oxaliplatin, are cornerstones in postoperative adjuvant therapy, management of locally advanced cases, and systemic treatment of recurrent/metastatic disease. However, their clinical efficacy is frequently hampered by severe systemic toxicities and the emergence of chemoresistance. To address these bottlenecks, diverse nano-delivery platforms have been engineered to enhance bioavailability and mitigate adverse effects. This review systematically delineates the evolution of first-to third-generation platinum drugs, elucidating their molecular mechanisms of action specifically within the landscape of cervical cancer. Furthermore, we critically evaluate the clinical application of these agents and provide a comprehensive synthesis of recent advances in nano-delivery systems, including targeted and stimuli-responsive carriers. By bridging traditional pharmacology with cutting-edge nanotechnology, this review offers strategic insights into achieving precise delivery and controlled release, potentially defining new paradigms for the next-generation of cervical cancer therapeutics.",
  "abstract_shown": true,
  "affiliations": [
    "School of Chemistry and Environmental Engineering, Changchun University of Science and Technology",
    "Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus",
    "Department of Obstetrics and Gynecology, Wenling Maternal and Child Healthcare Hospital"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Donghan Shao"
    },
    {
      "affs": [
        0
      ],
      "name": "Ping Gao"
    },
    {
      "affs": [
        0
      ],
      "name": "Qian Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuqin Ma"
    },
    {
      "affs": [
        1
      ],
      "name": "Irina Kolesnik"
    },
    {
      "affs": [
        1
      ],
      "name": "Vladimir Potkin"
    },
    {
      "affs": [
        0
      ],
      "name": "Leijiao Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Yongjun Teng"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ctt7bxe7p6qv4.bib",
  "cited_by": 0,
  "doi": "10.3389/fphar.2026.1794356",
  "fulltext_url": null,
  "id": "ctt7bxe7p6qv4",
  "issns": [
    "1663-9812"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1794356/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Metal complexes synthesis and properties"
    ]
  ],
  "openalex": "W7224106746",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-28",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/ctt7bxe7p6qv4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:06Z",
      "native_id": "10.3389/fphar.2026.1794356",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1794356/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Metal complexes synthesis and properties",
      "subfield": "oncology"
    }
  ],
  "title": "Advances in platinum-based drug development for cervical cancer therapy",
  "title_text": "Advances in platinum-based drug development for cervical cancer therapy",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:06Z",
  "url": "https://research.draconitic.com/paper/ctt7bxe7p6qv4",
  "venue": "Frontiers in Pharmacology",
  "versions": []
}