{
  "abstract": "Background: The fucoidan extracted from sea cucumber Pearsonothuria graeffei (Fuc-Pg) has beneficial anti-inflammatory and lipid-lowering effects, suggesting its potential anti-atherosclerotic properties.\n\nMethods: ApoE−/− mice were fed a high-fat diet (HFD) for 12 weeks. Fuc-Pg (20 mg/kg and 80 mg/kg) was administered by oral gavage once daily.\n\nResults: The results indicated that Fuc-Pg intervention reduced aortic plaques, suppressed systemic inflammation, and alleviated dyslipidemia in ApoE−/− mice. Mechanistically, Fuc-Pg reduced lipid absorption by decreasing CD36 and microsomal triglyceride transfer protein (MTP) expression levels in the small intestine, enhanced reverse cholesterol transport (RCT) by increasing hepatic LDLR and ABCG5, and facilitated bile acid synthesis by increasing CYP7A1 and CYP27A1 expression. Increased fecal lipid and hepatic bile acid levels further confirmed that Fuc-Pg exerted preventive effects in ApoE−/− mice by reducing lipid absorption.\n\nConclusion: Fuc-Pg alleviated atherosclerosis by modulating cholesterol metabolism and reducing lipid absorption. This study elucidates the nutritional application of fucoidan as a functional food ingredient and explores its potential mechanism.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Nutrition, Affiliated Hospital of Qingdao University, Qingdao University , ,",
    "Department of Cardiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology , ,",
    "Institute of Nutrition & Health, School of Public Health, Qingdao University , ,",
    "College of Biosystem Engineering and Food Science, Zhejiang University , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ting Zhao"
    },
    {
      "affs": [
        1
      ],
      "name": "Yang Yu"
    },
    {
      "affs": [
        2
      ],
      "name": "Yin Wang"
    },
    {
      "affs": [
        2
      ],
      "name": "Liyang Zhang"
    },
    {
      "affs": [
        2
      ],
      "name": "Junqi Xiao"
    },
    {
      "affs": [
        3
      ],
      "name": "Shiguo Chen"
    },
    {
      "affs": [
        2
      ],
      "name": "Shan Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ctvjsfv4k1mka.bib",
  "cited_by": 0,
  "doi": "10.3389/fnut.2026.1974149",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13724345/?tool=EBI",
  "id": "ctvjsfv4k1mka",
  "issns": [
    "2296-861X"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13724345",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "1104|Seaweed-derived Bioactive Compounds"
    ]
  ],
  "openalex": "W7222976642",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13724345/pdf/?tool=EBI",
  "pmcid": "PMC13724345",
  "pmid": "42973478",
  "published": "2026-10-19",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/ctvjsfv4k1mka.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:50Z",
      "native_id": "PMC:PMC13724345",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13724345"
    },
    {
      "first_seen": "2026-11-04T12:22:56Z",
      "native_id": "PMC13724345",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fnut.2026.1974149"
    },
    {
      "first_seen": "2026-11-04T15:20:48Z",
      "native_id": "MED:42973478",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42973478"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1104|Seaweed-derived Bioactive Compounds",
      "subfield": "ecology"
    }
  ],
  "title": "Fucoidan from Pearsonothuria graeffei alleviates dyslipidemia in ApoE−/− mice by regulating reverse cholesterol transport and promoting bile acid synthesis",
  "title_text": "Fucoidan from Pearsonothuria graeffei alleviates dyslipidemia in ApoE−/− mice by regulating reverse cholesterol transport and promoting bile acid synthesis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:21:07Z",
  "url": "https://research.draconitic.com/paper/ctvjsfv4k1mka",
  "venue": "Frontiers in nutrition",
  "versions": []
}