{
  "abstract": "Uterine fibroids (leiomyomas) are highly prevalent, noncancerous tumors canonically described as stiff and collagen-dense. Still, the mechanical heterogeneity within uterine fibroids and the alterations that occur at the fibroid-myometrium interface remain poorly understood. This study quantitatively maps the local mechanical, structural, and compositional properties of seedling uterine fibroids (< 1 cm) at the interface region. Relative to patient-matched myometrial tissues, uterine fibroids exhibited increased stiffness, decreased permeability, increased diffusivity, decreased hydration, greater collagen content, and distinct collagen organization. At the fibroid-myometrium interface, a band of aligned myometrial fibers immediately adjacent to the fibroid was observed, and heterogeneous spatial patterns in elastic modulus and permeability were identified. Ultimately, this study establishes foundational knowledge on the mechanics and structure of seedling uterine fibroids, facilitating future developments of clinically translatable detection tools.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biomedical Engineering, Columbia University, New York, NY USA",
    "Institute of Human Nutrition, Columbia University Irving Medical Center, New York, NY USA",
    "Program for Mathematical Genomics, Department of Systems Biology, Columbia University Irving Medical Center, New York, NY USA",
    "Department of Electrical Engineering, Columbia University, New York, NY USA",
    "Department of Obstetrics & Gynecology, Columbia University Irving Medical Center, New York, NY USA",
    "Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY USA",
    "Department of Biomedical Engineering, Wayne State University, Detroit, MI USA",
    "Department of Mechanical Engineering, Columbia University, New York, NY USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Daniella M. Fodera"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Alara Sutcu"
    },
    {
      "affs": [
        3
      ],
      "name": "Arielle S. Joasil"
    },
    {
      "affs": [
        3
      ],
      "name": "Aidan M. Therien"
    },
    {
      "affs": [
        0
      ],
      "name": "Johanna L. L. Jackson"
    },
    {
      "affs": [
        4
      ],
      "name": "Arnold P. Advincula"
    },
    {
      "affs": [
        5
      ],
      "name": "Xiaowei Chen"
    },
    {
      "affs": [
        3
      ],
      "name": "Christine P. Hendon"
    },
    {
      "affs": [
        6
      ],
      "name": "Michelle L. Oyen"
    },
    {
      "affs": [
        2,
        4
      ],
      "name": "Tal Korem"
    },
    {
      "affs": [
        7
      ],
      "name": "Kristin M. Myers"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ctvrw28effvh9.bib",
  "cited_by": 0,
  "doi": "10.1038/s44294-026-00152-9",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13719506/",
  "id": "ctvrw28effvh9",
  "issns": [
    "2948-1716"
  ],
  "landing_url": "https://doi.org/10.1038/s44294-026-00152-9",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2729|Uterine Myomas and Treatments"
    ]
  ],
  "openalex": "W4416407976",
  "pdf_url": "https://www.nature.com/articles/s44294-026-00152-9_reference.pdf",
  "pmcid": "PMC13719506",
  "pmid": "42964284",
  "published": "2026-07-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ctvrw28effvh9.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T12:23:27Z",
      "native_id": "PMC13719506",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s44294-026-00152-9"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2729|Uterine Myomas and Treatments",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Spatially mapping the mechanical and structural properties of the seedling uterine fibroid-myometrium interface",
  "title_text": "Spatially mapping the mechanical and structural properties of the seedling uterine fibroid-myometrium interface",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:20:33Z",
  "url": "https://research.draconitic.com/paper/ctvrw28effvh9",
  "venue": "Npj Women's Health",
  "versions": []
}