{
  "abstract": "Objective: The clinical management of colorectal cancer (CRC) is hampered by the frequent development of oxaliplatin (OXA) resistance. This study investigated whether exogenous L-carnitine (CAR) modulates OXA sensitivity in CRC cells and whether any such effect depends on fatty acid oxidation (FAO).\n\nMethods: The effects of carnitine, with or without OXA, on cell viability, proliferation, migration, oxygen consumption, apoptosis, cell-cycle distribution, and intracellular reactive oxygen species (ROS) were evaluated in HCT116 parental cells and an OXA-resistant subline (HCT116/L), using CCK-8, colony formation, wound healing, Seahorse XF analysis, flow cytometry, and ROS fluorescence probes.\n\nResults: In vitro , exogenous carnitine dose-dependently reduced CRC cell viability, proliferation, migration, and respiration, and promoted apoptosis. Co-treatment with carnitine partially attenuated the anti-proliferative and pro-apoptotic effects of OXA in HCT116/L cells, consistent with reduced chemosensitivity. This effect was accompanied by a partial restoration of fatty-acid-dependent respiration and a reduction in OXA-induced ROS accumulation.\n\nConclusion: In OXA-resistant HCT116/L (MSI-H) cells, exogenous carnitine is associated with reduced OXA sensitivity, an effect that requires fatty acid oxidation. These findings identify carnitine-FAO metabolism as a potential determinant of OXA response; whether limiting carnitine availability can restore OXA sensitivity in vivo remains a hypothesis to be tested.",
  "abstract_shown": true,
  "affiliations": [
    "Wenzhou Central Hospital",
    "Wenzhou Institute, University of Chinese Academy of Sciences"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yufang Fan"
    },
    {
      "affs": [
        0
      ],
      "name": "Jian Huang"
    },
    {
      "affs": [
        1
      ],
      "name": "Liqiang Dai"
    },
    {
      "affs": [
        0
      ],
      "name": "Lifeng Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuemiao Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongkai Cai"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiuru Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Wei Jiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Ziyi Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaoping Cai"
    },
    {
      "affs": [
        1
      ],
      "name": "Yao-Gen Shu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cv5zzvt6vn8g7.bib",
  "cited_by": 0,
  "doi": "10.3389/fphar.2026.1963206",
  "fulltext_url": null,
  "id": "cv5zzvt6vn8g7",
  "issns": [
    "1663-9812"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1963206/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1306|Cancer, Lipids, and Metabolism"
    ]
  ],
  "openalex": "W7224131778",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-28",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/cv5zzvt6vn8g7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:06Z",
      "native_id": "10.3389/fphar.2026.1963206",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1963206/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Cancer, Lipids, and Metabolism",
      "subfield": "oncology"
    }
  ],
  "title": "Exogenous carnitine can modulate oxaliplatin sensitivity in colorectal cancer cells in vitro",
  "title_text": "Exogenous carnitine can modulate oxaliplatin sensitivity in colorectal cancer cells in vitro",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:06Z",
  "url": "https://research.draconitic.com/paper/cv5zzvt6vn8g7",
  "venue": "Frontiers in Pharmacology",
  "versions": []
}