{
  "abstract": "Cancer recurrence remains a major challenge in prostate cancer (PCa), in part because quiescent cancer cells (QCCs) can survive conventional therapies and subsequently re-enter the cell cycle. Bioactive polysaccharides from food and medicinal mushrooms are increasingly investigated as nutraceutical ingredients for disease prevention and adjunctive health management. Polysaccharopeptide (PSP), a protein-bound polysaccharide derived from the mycelia of Coriolus versicolor , has a long history of oral use as an adjunctive bioactive preparation. Here, PSP inhibited QCC reactivation in LNCaP and PC-3 cells and restrained recurrent tumor growth in a quiescent PC-3 xenograft model. Mechanistically, PSP shortened the protein half-lives of Cyclin D3, CDK4, and CDK6, while proteasome inhibition attenuated their loss, supporting proteasome-dependent destabilization of the Cyclin D3–CDK4/6 axis. PSP also suppressed canonical and noncanonical NF-κB signaling, reduced nuclear accumulation of p65 and p52, and decreased NF-κB transcriptional activity, accompanied by decreased TNF-α and increased IL-10 expression. Oral PSP administration delayed recurrent tumor growth and prolonged overall survival in the xenograft model. Collectively, these findings identify QCC reactivation as a previously unrecognized cellular process responsive to PSP and provide mechanistic and preclinical support for further evaluation of this mushroom-derived bioactive preparation as an adjunctive strategy for recurrence-oriented PCa management.",
  "abstract_shown": true,
  "affiliations": [
    "School of Pharmacy, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Shanghai 201203, China; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, No. 1200, Cailun Road, Shanghai 201203, China",
    "School of Pharmacy, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Shanghai 201203, China; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, No. 1200, Cailun Road, Shanghai 201203, China; Corresponding authors at:",
    "School of Pharmacy, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Shanghai 201203, China; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, No. 1200, Cailun Road, Shanghai 201203, China; Biomedical Sciences and Chinese Medicine, School of Biological Sciences, Nanyang Technological University, Singapore; Corresponding authors at:"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mengfan Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xueyang Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiayi Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Rongchen Dai"
    },
    {
      "affs": [
        0
      ],
      "name": "Hangui Ren"
    },
    {
      "affs": [
        0
      ],
      "name": "Man Yuan"
    },
    {
      "affs": [
        1
      ],
      "name": "Yang Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhichao Xi"
    },
    {
      "affs": [
        2
      ],
      "name": "Hongxi Xu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cv7n66mh13826.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jff.2026.107557",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S175646462600407X",
  "id": "cv7n66mh13826",
  "issns": [
    "1756-4646",
    "2214-9414"
  ],
  "landing_url": "https://doi.org/10.1016/j.jff.2026.107557",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "TX341-641"
    ],
    [
      "openalex",
      "2736|Fungal Biology and Applications"
    ]
  ],
  "openalex": "W7223398606",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/cv7n66mh13826.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:33Z",
      "native_id": "9262d412760e4f70bd2e26f83a441ca2",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.jff.2026.107557"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2736|Fungal Biology and Applications",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Polysaccharopeptide from",
  "title_text": "Polysaccharopeptide from",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:33Z",
  "url": "https://research.draconitic.com/paper/cv7n66mh13826",
  "venue": "Journal of Functional Foods",
  "versions": []
}