{
  "abstract": "Adenosine deaminase acting on RNA 1 (ADAR1) has emerged as an important cancer dependency and suppressor of innate immunity. While early therapeutic strategies focused on global enzymatic inhibition, these approaches may compromise essential homeostatic functions of the constitutively expressed ADAR1-p110 isoform. Growing evidence highlights editing-independent functions uniquely mediated by the interferon-inducible ADAR1-p150 isoform. Through its conformation-specific Zα domain, ADAR1-p150 binds Z-nucleic acids and suppresses MDA5-, PKR-, and ZBP1-driven innate immune activation, thereby promoting tumor immune evasion and adaptation to inflammatory stress. Consequently, selectively disrupting this p150-mediated suppression may represent a more therapeutically tractable strategy than global ADAR1 inhibition, with the Zα domain providing a potentially selective mechanistic interface. This review synthesizes current understanding of Zα-mediated immune regulation, evaluates emerging domain-specific therapeutic approaches, and provides a comprehensive guide to the biophysical and cell-based assays used to interrogate Zα interactions, highlighting key mechanistic gaps that may inform future p150-selective translational interventions.",
  "abstract_shown": true,
  "affiliations": [
    "Translational Cancer Biology, Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia",
    "Department of Biomedical Science, Pusat Kanser Tun Abdullah Ahmad Badawi, Universiti Sains Malaysia, Pulau Pinang, Malaysia",
    "School of Research, Faculty of Chemical Engineering and Science, Swinburne University of Technology Sarawak Campus, Kuching, Sarawak, Malaysia",
    "School of Science, Monash University Malaysia, Subang Jaya, Selangor, Malaysia",
    "Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore",
    "Department of Oral & Maxillofacial Clinical Sciences, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia",
    "Oral Cancer Research and Coordinating Centre (OCRCC), Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Jie Ying Teo",
      "orcid": "0009-0004-2255-8344"
    },
    {
      "affs": [
        0
      ],
      "name": "Pei San Yee"
    },
    {
      "affs": [
        1
      ],
      "name": "Sarah Azrai"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Stephanie Hao Ling Cheah"
    },
    {
      "affs": [
        1
      ],
      "name": "Siew Kit Ng"
    },
    {
      "affs": [
        3
      ],
      "name": "Keng Yoon Yeong"
    },
    {
      "affs": [
        2,
        4
      ],
      "name": "Xavier Wezen Chee"
    },
    {
      "affs": [
        2
      ],
      "name": "Siaw San Hwang"
    },
    {
      "affs": [
        0,
        5,
        6
      ],
      "name": "Sok Ching Cheong"
    },
    {
      "affs": [
        0
      ],
      "name": "Annie Wai Yeeng Chai",
      "orcid": "0000-0002-8015-6050"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cvbygxxe1en7h.bib",
  "cited_by": 0,
  "doi": "10.1080/15384047.2026.2749935",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13733150/",
  "id": "cvbygxxe1en7h",
  "issns": [
    "1538-4047",
    "1555-8576"
  ],
  "landing_url": "https://doi.org/10.1080/15384047.2026.2749935",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review Article"
    ],
    [
      "openalex",
      "1312|RNA regulation and disease"
    ]
  ],
  "openalex": "W7224827881",
  "pdf_url": "https://www.tandfonline.com/doi/pdf/10.1080/15384047.2026.2749935?needAccess=true",
  "pmcid": "PMC13733150",
  "pmid": "42961781",
  "published": "2026-10-30",
  "publisher": "Taylor & Francis",
  "ris": "https://research.draconitic.com/paper/cvbygxxe1en7h.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:23:00Z",
      "native_id": "PMC13733150",
      "source": "pmc",
      "url": "https://doi.org/10.1080/15384047.2026.2749935"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|RNA regulation and disease",
      "subfield": "molecular-biology"
    }
  ],
  "title": "The Zα domain of ADAR1: emerging roles in cancer biology and evidence as a promising therapeutic target",
  "title_text": "The Zα domain of ADAR1: emerging roles in cancer biology and evidence as a promising therapeutic target",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:23:00Z",
  "url": "https://research.draconitic.com/paper/cvbygxxe1en7h",
  "venue": "Cancer Biology & Therapy",
  "versions": []
}