{
  "abstract": "In mouse models of pancreatic ductal adenocarcinoma, surgical removal of orthotopic tumors typically involves removing the primary tumor along with the spleen. Here, we present a protocol for surgical removal of the tumor in the tail of the pancreas while preserving the spleen. We describe steps for implantation of mouse pancreatic cancer cells followed by the identification and removal of the orthotopic tumor. We also outline perioperative treatment strategies for tumor recurrence.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada; Centre de Recherche Du Centre Hospitalier de L'Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.",
    "Department of Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada; Centre de Recherche Du Centre Hospitalier de L'Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada; Department of Surgery, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.",
    "Centre de Recherche Du Centre Hospitalier de L'Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada; Department of Surgery, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.",
    "Department of Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada; Centre de Recherche Du Centre Hospitalier de L'Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada. Electronic address: lee-hwa.tai@usherbrooke.ca."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jacob L Léger"
    },
    {
      "affs": [
        1
      ],
      "name": "Nawal Amhis"
    },
    {
      "affs": [
        1
      ],
      "name": "Sarah Mansouri"
    },
    {
      "affs": [
        0
      ],
      "name": "Maria Fernanda Meza Pacheco"
    },
    {
      "affs": [
        0
      ],
      "name": "Lauren Daniel"
    },
    {
      "affs": [
        0
      ],
      "name": "Hugo Giguère",
      "orcid": "0000-0001-7193-0051"
    },
    {
      "affs": [
        2
      ],
      "name": "Yves Collin"
    },
    {
      "affs": [
        3
      ],
      "name": "Lee-Hwa Tai"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cvf0wm8wqk3t4.bib",
  "cited_by": 0,
  "doi": "10.1016/j.xpro.2026.104897",
  "fulltext_url": "https://europepmc.org/articles/PMC13675828",
  "id": "cvf0wm8wqk3t4",
  "issns": [
    "2666-1667"
  ],
  "landing_url": "https://europepmc.org/article/MED/42858257",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Pancreatic and Hepatic Oncology Research"
    ]
  ],
  "openalex": "W7221349908",
  "pdf_url": "https://europepmc.org/articles/PMC13675828?pdf=render",
  "pmcid": "PMC13675828",
  "pmid": "42858257",
  "published": "2026-10-10",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cvf0wm8wqk3t4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42858257",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42858257"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Pancreatic and Hepatic Oncology Research",
      "subfield": "oncology"
    }
  ],
  "title": "Protocol for an immunocompetent KPC mouse model of pancreatic cancer resection and recurrence for perioperative treatment studies.",
  "title_text": "Protocol for an immunocompetent KPC mouse model of pancreatic cancer resection and recurrence for perioperative treatment studies.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/cvf0wm8wqk3t4",
  "venue": "STAR protocols",
  "versions": []
}