{
  "abstract": "Rhythmic gene expression is controlled by oscillating recruitment of specific transcription factors and co-regulators, including histone-modifying enzymes and chromatin-remodeling complexes. To unravel the significance of SWI/SNF ATPase subunits in diurnal chromatin remodeling, we have mapped diurnal chromatin accessibility, SWI/SNF occupancy, and gene expression throughout a day in the liver of male mice exposed to a night restricted feeding regimen. We find remarkable remodeling during fasting-to-fed transitions, and a third of rhythmic enhancers exhibited diurnal SWI/SNF occupancy and accessibility. Hepatocyte-specific disruption of either of the two mutually exclusive ATPases of SWI/SNF has minor effects on chromatin accessibility. However, simultaneous disruption of both ATPases results in a collapse of chromatin accessibility in the majority of distal cis-regulatory and a third of promoter proximal cis-regulatory elements, which leads to disrupted diurnal gene expression and signs of liver damage and inflammation. SWI/SNF-dependent promoters exhibit similarities with diurnal promoters, indicating a potential sequence-level bias that favors dynamic SWI/SNF-mediated chromatin remodeling. Collectively, this suggests an essential role of SWI/SNF-mediated chromatin remodeling of cis-regulatory regions for rhythmic gene expression and basic liver function.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark.",
    "Institute of Neurobiology, Center of Brain, Behavior & Metabolism, University of Lübeck, Lübeck, Germany.",
    "Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark. larsgr@bmb.sdu.dk."
  ],
  "article_type": "research support, non u.s. gov't",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Nicolaj I Toft"
    },
    {
      "affs": [
        0
      ],
      "name": "Victor E Goitea",
      "orcid": "0000-0002-1564-4111"
    },
    {
      "affs": [
        0
      ],
      "name": "Stine M Præstholm",
      "orcid": "0000-0002-3902-1015"
    },
    {
      "affs": [
        0
      ],
      "name": "Catarina M Correia",
      "orcid": "0000-0002-8562-0086"
    },
    {
      "affs": [
        1
      ],
      "name": "Isabel Heyde",
      "orcid": "0000-0002-8471-6457"
    },
    {
      "affs": [
        0
      ],
      "name": "Majken S Siersbæk"
    },
    {
      "affs": [
        1
      ],
      "name": "Henrik Oster",
      "orcid": "0000-0002-1414-7068"
    },
    {
      "affs": [
        2
      ],
      "name": "Lars Grøntved",
      "orcid": "0000-0002-6735-8483"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cw01n915hd24v.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-77798-1",
  "fulltext_url": "https://europepmc.org/articles/PMC13683358",
  "id": "cw01n915hd24v",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://europepmc.org/article/MED/42901890",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Chromatin Remodeling and Cancer"
    ]
  ],
  "openalex": "W7213663886",
  "pdf_url": "https://europepmc.org/articles/PMC13683358?pdf=render",
  "pmcid": "PMC13683358",
  "pmid": "42901890",
  "published": "2026-09-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cw01n915hd24v.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:41Z",
      "native_id": "MED:42901890",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42901890"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Chromatin Remodeling and Cancer",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Disruption of SWI/SNF ATPases in the mouse liver impairs diurnal gene expression associated with specific promoter features.",
  "title_text": "Disruption of SWI/SNF ATPases in the mouse liver impairs diurnal gene expression associated with specific promoter features.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:41Z",
  "url": "https://research.draconitic.com/paper/cw01n915hd24v",
  "venue": "Nature communications",
  "versions": []
}