{
  "abstract": "Hypoxic-ischemic encephalopathy (HIE) causes severe neonatal brain injury, with PARP1 hyperactivation implicated in neuronal death. Using a rat HIE model and glutamate-exposed HT22 neurons, we found that miR-7a-5p is significantly downregulated in both peripheral blood and the injured cortex of HIE rats. PARP1 hyperactivation triggered parthanatos, characterized by PAR polymer accumulation and apoptosis-inducing factor (AIF) nuclear translocation, without activating caspase-dependent apoptosis. Luciferase assays confirmed direct targeting of miR-7a-5p to the 3′ UTR of PARP1, suppressing its expression. Exogenous miR-7a-5p reduces infarction volume, improves neural morphology, and preserves neurological function recovery in HIE rats. In vitro, miR-7a-5p overexpression or pharmacological PARP1 inhibition attenuated glutamate-induced neuronal death, mitochondrial membrane potential (MMP) loss, ROS overproduction, and PAR/AIF dysregulation. Crucially, PARP1 agonist MNNG reversed miR-7a-5p-mediated neuroprotection, establishing the indispensability of the miR-7a-5p/PARP1 axis. miR-7a-5p is a key regulator of parthanatos, suppressing PARP1 hyperactivation, mitigating mitochondrial dysfunction, and offering a therapeutic target for HIE.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Danmei Chen"
    },
    {
      "name": "Xiangyu Kong"
    },
    {
      "name": "Hequan Zhong"
    },
    {
      "name": "Yunpeng Zhang"
    },
    {
      "name": "Chenqin Si"
    },
    {
      "name": "Ayipaxiaguli Kasimu"
    },
    {
      "name": "Rui Qiao"
    },
    {
      "name": "Yuting Song"
    },
    {
      "name": "Bing Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cw1gkehshz34p.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.117947",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13734944/",
  "id": "cw1gkehshz34p",
  "issns": [
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  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03330-4",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "heading",
      "Biological sciences"
    ],
    [
      "openalex",
      "2735|Neonatal and fetal brain pathology"
    ]
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  "openalex": "W7223681130",
  "pdf_url": null,
  "pmcid": "PMC13734944",
  "pmid": "42990635",
  "published": "2026-10-26",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/cw1gkehshz34p.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:16Z",
      "native_id": "10.1016/j.isci.2026.117947",
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      "url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03330-4"
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      "first_seen": "2026-10-30T12:17:49Z",
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      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589004226033304"
    },
    {
      "first_seen": "2026-11-09T12:20:44Z",
      "native_id": "PMC13734944",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.isci.2026.117947"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2735|Neonatal and fetal brain pathology",
      "subfield": "reproductive-child"
    }
  ],
  "title": "miR-7a-5p attenuates hypoxic-ischemic encephalopathy by suppressing PARP1-mediated parthanatos",
  "title_text": "miR-7a-5p attenuates hypoxic-ischemic encephalopathy by suppressing PARP1-mediated parthanatos",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:20:44Z",
  "url": "https://research.draconitic.com/paper/cw1gkehshz34p",
  "venue": "iScience",
  "versions": []
}