{
  "abstract": "Introduction\n\nRelapsed/refractory post-transplant lymphoproliferative disorder (PTLD) remains a challenging complication after solid organ transplantation (SOT), requiring complex balancing of immune-suppressive therapy (IST) and lymphoma-directed therapies.Methods\n\nWe report the case of a 40-year-old female kidney-pancreas transplant recipient with relapsing monomorphic PTLD treated with CD19-chimeric antigen receptor (CAR) T cells therapy (axicabtagene ciloleucel).Results\n\nTacrolimus discontinuation and immunosuppression with everolimus and corticosteroids permitted robust CAR T-cell expansion, complete lymphoma remission, and preservation of graft function. In vitro studies showed that tacrolimus inhibited CAR T-cell function, while everolimus preserved it, supporting the use of mTOR-based, calcineurin-inhibitor-free IST during CAR T-cell therapy in SOT recipients.Conclusion\n\nmTOR-based, calcineurin inhibitor-free immunosuppression can preserve CAR T-cell function and enable effective therapy in SOT recipients with PTLD.",
  "abstract_shown": true,
  "affiliations": [
    "Geneva University Hospitals",
    "University of Geneva",
    "Geneva University Hospital",
    "Università Della Svizzera Italiana"
  ],
  "article_type": "brief report",
  "arxiv": null,
  "author_total": 22,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Maria Mappoura"
    },
    {
      "affs": [
        0
      ],
      "name": "Yara Hajj Younes"
    },
    {
      "affs": [
        1
      ],
      "name": "Sisi Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Kadiatou Baldet"
    },
    {
      "affs": [
        0
      ],
      "name": "Carmen De Ramon Ortiz"
    },
    {
      "affs": [
        0
      ],
      "name": "Sarah Morin"
    },
    {
      "affs": [
        0
      ],
      "name": "Stavroula Marouridi‐Levrat"
    },
    {
      "affs": [
        0
      ],
      "name": "Amandine Pradier"
    },
    {
      "affs": [
        1
      ],
      "name": "Astrid Melotti"
    },
    {
      "affs": [
        1
      ],
      "name": "Pragallabh Purwar"
    },
    {
      "affs": [
        0
      ],
      "name": "Chiara Bernardi"
    },
    {
      "affs": [
        2
      ],
      "name": "Liza Ho"
    },
    {
      "affs": [
        2
      ],
      "name": "Kristof Egervari"
    },
    {
      "affs": [
        2
      ],
      "name": "Julie Ducreux"
    },
    {
      "affs": [
        0
      ],
      "name": "Thomas Longval"
    },
    {
      "affs": [
        3
      ],
      "name": "Francesco Bertoni"
    },
    {
      "affs": [
        0
      ],
      "name": "Yves Chalandon"
    },
    {
      "affs": [
        0
      ],
      "name": "Fadi Haidar"
    },
    {
      "affs": [
        0
      ],
      "name": "Sophie de Seigneux"
    },
    {
      "affs": [
        1
      ],
      "name": "Jean Villard"
    },
    {
      "affs": [
        1
      ],
      "name": "Valérie Olivier"
    },
    {
      "affs": [
        0
      ],
      "name": "Federico Simonetta"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cw1s98cgwbhg5.bib",
  "cited_by": 0,
  "doi": "10.1002/jha2.70437",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717070/?tool=EBI",
  "id": "cw1s98cgwbhg5",
  "issns": [
    "2688-6146"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13717070",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Short Report"
    ],
    [
      "openalex",
      "2730|CAR-T cell therapy research"
    ]
  ],
  "openalex": "W7224519364",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717070/pdf/?tool=EBI",
  "pmcid": "PMC13717070",
  "pmid": "42959460",
  "published": "2026-10-28",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/cw1s98cgwbhg5.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:37Z",
      "native_id": "PMC:PMC13717070",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13717070"
    },
    {
      "first_seen": "2026-11-01T00:20:50Z",
      "native_id": "MED:42959460",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42959460"
    },
    {
      "first_seen": "2026-11-02T12:21:27Z",
      "native_id": "PMC13717070",
      "source": "pmc",
      "url": "https://doi.org/10.1002/jha2.70437"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|CAR-T cell therapy research",
      "subfield": "oncology"
    }
  ],
  "title": "Calcineurin Inhibitor–Free, mTOR‐Based Immunosuppression in Chimeric Antigen Receptor T‐Cell Therapy for Post‐Transplant Lymphoproliferative Disorder",
  "title_text": "Calcineurin Inhibitor–Free, mTOR‐Based Immunosuppression in Chimeric Antigen Receptor T‐Cell Therapy for Post‐Transplant Lymphoproliferative Disorder",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:21:27Z",
  "url": "https://research.draconitic.com/paper/cw1s98cgwbhg5",
  "venue": "EJHaem",
  "versions": []
}