{
  "abstract": "Prophylactic human papillomavirus (HPV) vaccines prevent new infections but do not treat established HPV-associated lesions, highlighting the need for therapeutic strategies targeting viral tumor antigens. We developed a recombinant overlapping peptide-based HPV16 E7 vaccine (ROP-E7) and evaluated its immunogenicity and antitumor activity, alone or combined with CD137 (4-1BB) agonism, in C57BL/6 mice. In tumor-free mice, ROP-E7 induced greater helper and cytotoxic T cell responses than wild-type E7. In tumor-bearing mice, ROP-E7 reduced tumor burden and improved survival, while combination treatment induced complete tumor regression and tumor-free survival beyond 100 days. These effects were associated with increased intratumoral cytotoxic T cells and reduced regulatory and exhausted T cell populations. These findings provide preclinical support for combining therapeutic HPV16 E7 vaccination with T cell co-stimulation in HPV-associated cancers.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "Yuqian Ou"
    },
    {
      "name": "Wenshu Lu"
    },
    {
      "name": "Hanjun Zhao"
    },
    {
      "name": "Constantinos Demetrious"
    },
    {
      "name": "Qing Zhang"
    },
    {
      "name": "Qiujie Zheng"
    },
    {
      "name": "Yanyan Jiang"
    },
    {
      "name": "Peter Kok-Ting Wan"
    },
    {
      "name": "Eric O’Neill"
    },
    {
      "name": "Lina Zhang"
    },
    {
      "name": "Shisong Jiang",
      "orcid": "0000-0003-2103-6929"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cw1vywj94bsqf.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.118018",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13734790/",
  "id": "cw1vywj94bsqf",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03401-2",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "heading",
      "Immunology"
    ],
    [
      "heading",
      "Microenvironment"
    ],
    [
      "openalex",
      "2403|Immunotherapy and Immune Responses"
    ]
  ],
  "openalex": "W7223693028",
  "pdf_url": "https://www.cell.com/iscience/pdf/S2589-0042(26)03401-2.pdf",
  "pmcid": "PMC13734790",
  "pmid": "42990593",
  "published": "2026-10-26",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/cw1vywj94bsqf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:16Z",
      "native_id": "10.1016/j.isci.2026.118018",
      "source": "feed-cell",
      "url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03401-2"
    },
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "10.1016/j.isci.2026.118018",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589004226034012"
    },
    {
      "first_seen": "2026-11-09T12:20:37Z",
      "native_id": "PMC13734790",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.isci.2026.118018"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "heading:Immunology",
      "subfield": "immunology"
    }
  ],
  "title": "Therapeutic HPV16 E7 vaccination with CD137 agonism induces tumor regression and durable immunity in mice",
  "title_text": "Therapeutic HPV16 E7 vaccination with CD137 agonism induces tumor regression and durable immunity in mice",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:20:37Z",
  "url": "https://research.draconitic.com/paper/cw1vywj94bsqf",
  "venue": "iScience",
  "versions": []
}