{
  "abstract": "We present a rare case of type I GD with frequent bone complications. After multiple fractures the patient received 5 mg zoledronic acid hydrate, which improved TRACP-5b and P1NP levels. After 1 year, TRACP-5b levels increased significantly, and the patient received SRT therapy complemented with eldecalcitol for vitamin D deficiency. One year later, bone density had improved and bone metabolism markers remained within normal levels.\n\nOsteoporosis treatment is a potential strategy for GD-related bone symptoms.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Orthopaedic Surgery, Kawasaki Municipal Tama Hospital by Designated Administrator Educational Foundation, St. Marianna University School of Medicine, Kawasaki, Kanagawa, 214-8525, Japan",
    "Department of Orthopaedic Surgery, St. Marianna University School of Medicine, Kawasaki, Kanagawa, 216-8511, Japan"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hiroyuki Onuma"
    },
    {
      "affs": [
        1
      ],
      "name": "Naoki Haraguchi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cwbvkswhgkx5z.bib",
  "cited_by": 0,
  "doi": "10.1016/j.bonr.2026.101962",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13734787/",
  "id": "cwbvkswhgkx5z",
  "issns": [
    "2352-1872"
  ],
  "landing_url": "https://doi.org/10.1016/j.bonr.2026.101962",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "openalex",
      "2716|Lysosomal Storage Disorders Research"
    ]
  ],
  "openalex": "W7223049878",
  "pdf_url": null,
  "pmcid": "PMC13734787",
  "pmid": "42990837",
  "published": "2026-10-20",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/cwbvkswhgkx5z.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:20:37Z",
      "native_id": "PMC13734787",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.bonr.2026.101962"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Lysosomal Storage Disorders Research",
      "subfield": "human-genetics"
    }
  ],
  "title": "Changes in bone density and metabolism marker levels in type I Gaucher's disease following annual zoledronic acid hydrate administration: A case report",
  "title_text": "Changes in bone density and metabolism marker levels in type I Gaucher's disease following annual zoledronic acid hydrate administration: A case report",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:20:37Z",
  "url": "https://research.draconitic.com/paper/cwbvkswhgkx5z",
  "venue": "Bone Reports",
  "versions": []
}