{
  "abstract": "ObjectiveTo evaluate the safety and clinical performance of a high-purity, non-cross-linked 1.0% sodium hyaluronate administered via intra-articular injection in patients with symptomatic knee osteoarthritis (OA).DesignThis 30-week, single-center, open-label post-market clinical performance evaluation enrolled adults with radiographically confirmed knee OA. Participants received five weekly intra-articular injections of 1.0% sodium hyaluronate. Resting pain (VAS), Kellgren-Lawrence (KL) grade, and patient satisfaction were assessed through Week 30, and adverse events were monitored throughout.ResultsMean VAS pain scores decreased by 48.3% at Week 8 and 42.8% at Week 30 compared with baseline (both p < 0.001). KL grades were generally stable over time, with no clear radiographic worsening observed during follow-up. Approximately 90% of patients reported satisfaction with treatment, and no treatment-related serious adverse events occurred.ConclusionsFive weekly intra-articular injections of 1.0% sodium hyaluronate were well tolerated and were associated with reductions in resting pain and stable radiographic findings over 30 weeks, supporting its role as a well-tolerated viscosupplementation option in routine clinical care for knee OA.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Orthopaedic Surgery, Tri-Service General Hospital, School of Medicine, National Defense Medical University, Taipei, Taiwan.",
    "Maxigen Biotech Inc., Taoyuan, Taiwan.",
    "Research & Design Center, TCI Co., Ltd., Taipei, Taiwan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Tsu-Te Yeh"
    },
    {
      "affs": [
        1
      ],
      "name": "Ching-Ting Chen"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Yung-Hsiang Lin"
    },
    {
      "affs": [
        2
      ],
      "name": "Chi-Fu Chiang"
    },
    {
      "affs": [
        2
      ],
      "name": "Yi-Wen Mao",
      "orcid": "0000-0002-6729-9946"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cwfrxc73fs425.bib",
  "cited_by": 0,
  "doi": "10.1177/19476035261493633",
  "fulltext_url": "https://europepmc.org/articles/PMC13683830",
  "id": "cwfrxc73fs425",
  "issns": [
    "1947-6035",
    "1947-6043"
  ],
  "landing_url": "https://europepmc.org/article/MED/42900674",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2745|Osteoarthritis Treatment and Mechanisms"
    ]
  ],
  "openalex": "W7223009360",
  "pdf_url": "https://europepmc.org/articles/PMC13683830?pdf=render",
  "pmcid": "PMC13683830",
  "pmid": "42900674",
  "published": "2026-10-20",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cwfrxc73fs425.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:32Z",
      "native_id": "MED:42900674",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42900674"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2745|Osteoarthritis Treatment and Mechanisms",
      "subfield": "general"
    }
  ],
  "title": "Real-World Evaluation of Repeated Intra-articular 1.0% Sodium Hyaluronate Injections for Knee Osteoarthritis: A 30-Week Post-market Clinical Performance Study.",
  "title_text": "Real-World Evaluation of Repeated Intra-articular 1.0% Sodium Hyaluronate Injections for Knee Osteoarthritis: A 30-Week Post-market Clinical Performance Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:32Z",
  "url": "https://research.draconitic.com/paper/cwfrxc73fs425",
  "venue": "Cartilage",
  "versions": []
}