{
  "abstract": "Avicennia marina (Forssk.) Vierh. is an important mangrove plant with high nutritional and medicinal values, featuring saccharides as its primary bioactive compounds. In this study, we successfully isolated a neutral tetrasaccharide (AMO-1) from the fruits of A. marina. Through monosaccharide composition, methylation, UPLC-ESI-MS/MS, and NMR analyses, we revealed that the structure of AMO-1 was α-D-Galp-(1 → 6)-α-D-Galp-(1 → 6)-α-D-Glcp-(1 → 2)-β-D-Fruf. Subsequently, we investigated the anti-osteoporosis (anti-OP) efficacy and underlying mechanisms of AMO-1. Our findings demonstrated that AMO-1 promoted the differentiation and mineralization of MC3T3-E1 cells. Furthermore, AMO-1 increased trabecular bone density and restored its reticular structure in dexamethasone-induced OP mice. Additionally, AMO-1 upregulated the expression levels of osteogenic factors and elevated serum levels of osteocalcin and PINP. Mechanistically, AMO-1 promoted osteogenesis through activation of the PI3K/AKT/HIF-1α signaling pathway, thus exerting anti-OP effects. Overall, these findings indicate that AMO-1 is a promising functional food ingredient with therapeutic potential for the prevention and management of OP.",
  "abstract_shown": true,
  "affiliations": [
    "The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, 524023, People's Republic of China.",
    "Department of Environmental Science and Engineering, Fudan University, Shanghai, 200438, People's Republic of China.",
    "The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, 524023, People's Republic of China. winokhere@sina.com.",
    "Guangdong Engineering Technology Research Center for the Development and Utilization of Mangrove Wetland Medicinal Resources, Guangdong Medical University, Zhanjiang, 524023, People's Republic of China. winokhere@sina.com.",
    "College of Tropical Southern Medicinal Herbs and Marine Organism Utilization, Guangdong Medical University, Zhanjiang, 524023, People's Republic of China. winokhere@sina.com.",
    "The Marine Biomedical Research Institute of Guangdong Zhanjiang, School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, 524023, People's Republic of China. lumingdeng@gdmu.edu.cn.",
    "Guangdong Engineering Technology Research Center for the Development and Utilization of Mangrove Wetland Medicinal Resources, Guangdong Medical University, Zhanjiang, 524023, People's Republic of China. lumingdeng@gdmu.edu.cn.",
    "College of Tropical Southern Medicinal Herbs and Marine Organism Utilization, Guangdong Medical University, Zhanjiang, 524023, People's Republic of China. lumingdeng@gdmu.edu.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Lishuang Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhenhui Feng"
    },
    {
      "affs": [
        0
      ],
      "name": "Yijing Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Lei Tan"
    },
    {
      "affs": [
        0
      ],
      "name": "Pan Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Xia Wu"
    },
    {
      "affs": [
        1
      ],
      "name": "Xing Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Qinyuan Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiwen Cai"
    },
    {
      "affs": [
        0
      ],
      "name": "Liutong Yu"
    },
    {
      "affs": [
        2,
        3,
        4
      ],
      "name": "Kefeng Wu"
    },
    {
      "affs": [
        5,
        6,
        7
      ],
      "name": "Luming Deng",
      "orcid": "0009-0006-4304-6350"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cwj7hynbrcz3a.bib",
  "cited_by": 0,
  "doi": "10.1007/s13659-026-00646-8",
  "fulltext_url": "https://europepmc.org/articles/PMC13691021",
  "id": "cwj7hynbrcz3a",
  "issns": [
    "2192-2195",
    "2192-2209"
  ],
  "landing_url": "https://europepmc.org/article/MED/42911466",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
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      "QK1-989"
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      "openalex",
      "1312|Bone Metabolism and Diseases"
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  "pdf_url": "https://europepmc.org/articles/PMC13691021?pdf=render",
  "pmcid": "PMC13691021",
  "pmid": "42911466",
  "published": "2026-10-22",
  "publisher": "SpringerOpen",
  "ris": "https://research.draconitic.com/paper/cwj7hynbrcz3a.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42911466",
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  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Bone Metabolism and Diseases",
      "subfield": "molecular-biology"
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  ],
  "title": "Isolation, structural characterization of oligosaccharide AMO-1 from Avicennia marina fruit and its anti-osteoporotic effects via PI3K/AKT/HIF‑1α signaling pathway activation.",
  "title_text": "Isolation, structural characterization of oligosaccharide AMO-1 from Avicennia marina fruit and its anti-osteoporotic effects via PI3K/AKT/HIF‑1α signaling pathway activation.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:32Z",
  "url": "https://research.draconitic.com/paper/cwj7hynbrcz3a",
  "venue": "Natural products and bioprospecting",
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}