{
  "abstract": "Breast carcinosarcoma is a rare and highly aggressive subtype of metaplastic breast carcinoma. It is typically negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2), and displays greater invasiveness and metastatic potential than triple-negative breast cancer (TNBC). This exploratory single-case study analyzed one individual breast carcinosarcoma sample via single-cell RNA sequencing, which revealed that the tumor was predominantly composed of epithelial cells and fibroblasts, with four distinct subpopulations identified for each cell type. In this case, critical crosstalk between malignant epithelial cells and mesenchymal cells may be mediated by the LAMININ, MK, and APP signaling pathways. Comparative analysis of single-cell sequencing data from this sample with publicly available TNBC single-cell datasets revealed notable differences in cellular composition between this breast carcinosarcoma case and TNBC samples. Whole-genome sequencing of the sample identified complex genomic alterations, including potential germline susceptibility-related candidate genes and candidate driver mutations associated with the tumor in this case. This study presents single-cell transcriptomic and whole-genomic profiling data for a single case of breast carcinosarcoma, deepens understanding of the biological characteristics of this tumor in the studied case, and provides a novel exploratory resource for investigating the heterogeneity of breast carcinosarcoma.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Breast and Thyroid Surgery, Ward Three, Affiliated Zhongshan Hospital of Dalian University",
    "Teaching Laboratory of Morphology, College of Basic Medical Sciences, Dalian Medical University",
    "Department of Pathology, Affiliated Zhongshan Hospital of Dalian University",
    "Department of Breast Surgery, The Second Hospital of Dalian Medical University",
    "Department of Oncology, Affiliated Zhongshan Hospital of Dalian University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Meiling Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Luhan Xie"
    },
    {
      "affs": [
        0
      ],
      "name": "Guangze Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Yue Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiping Xie"
    },
    {
      "affs": [
        2
      ],
      "name": "Weipeng Lv"
    },
    {
      "affs": [
        0
      ],
      "name": "Shilin Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Yi Wan"
    },
    {
      "affs": [
        0
      ],
      "name": "Min Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhantian Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Shiyu Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaomin Fu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jingfan Xia"
    },
    {
      "affs": [
        3
      ],
      "name": "Zuowei Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Yongqiang Yao"
    },
    {
      "affs": [
        4
      ],
      "name": "Ruoyu Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cwma5ppk610sm.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-61487-6",
  "fulltext_url": "https://doi.org/10.1038/s41598-026-61487-6",
  "id": "cwma5ppk610sm",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://doi.org/10.1038/s41598-026-61487-6",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "Q"
    ],
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "1312|Single-cell and spatial transcriptomics"
    ]
  ],
  "openalex": "W7169658358",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/cwma5ppk610sm.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:59Z",
      "native_id": "e30f5d6d582143b7b143084bf2c8e9c9",
      "source": "doaj",
      "url": "https://doi.org/10.1038/s41598-026-61487-6"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Single-cell and spatial transcriptomics",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Single-cell transcriptomics and whole-genome sequencing reveal the tumor landscape in breast carcinosarcoma",
  "title_text": "Single-cell transcriptomics and whole-genome sequencing reveal the tumor landscape in breast carcinosarcoma",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:59Z",
  "url": "https://research.draconitic.com/paper/cwma5ppk610sm",
  "venue": "Scientific Reports",
  "versions": []
}