{
  "abstract": "Objective\n\nTo evaluate the diagnostic and prognostic value of incidentally detected coronary artery calcification (CAC) on routine chest computed tomography (CT) for cardiovascular risk stratification in patients with idiopathic inflammatory myopathies (IIM).Methods\n\nIn this single-centre cross-sectional study, adult patients with IIM who underwent non-cardiac, non-gated high-resolution chest CT (HRCT) were included. CAC was visually categorized as absent, mild, moderate or severe. Diagnostic performance for established coronary artery disease (CAD) and established cardiovascular (CV) events was assessed. Kaplan-Meier analyses evaluated CV death-free survival, and multivariable logistic regression identified factors associated with CAC. A matched systemic sclerosis (SSc) cohort served as validation cohort.Results\n\nAmong 234 patients with IIM (mean age 57.1 [15.9] years; 70.1% female), CAC was present in 43.2%. Higher CAC thresholds showed greater specificity for established CAD and prior CV events, whereas lower thresholds were more sensitive. CAC was associated with reduced CV death-free survival (log-rank P = 0.0095), with a stepwise decline across CAC severity categories. Findings were similar in the matched SSc cohort. Increasing CAC burden was associated with older age, smoking, higher CV risk burden, interstitial lung disease and higher disease activity. In adjusted analyses, high disease activity was independently associated with moderate CAC (odds ratio [OR] 4.01; 95% CI: 1.29, 12.50), while a higher number of concomitant DMARDs was associated with severe CAC (OR 2.55; 95% CI: 1.27, 5.11).Conclusion\n\nIncidentally detected CAC on routine chest CT provides diagnostic and prognostic information in IIM and may represent a pragmatic approach to improve cardiovascular risk stratification in this high-risk population.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.",
    "Department of Rheumatology, Oslo University Hospital, Oslo, Norway.",
    "Division of General and Paediatric Radiology, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.",
    "Imaging Verbund, Vienna, Austria.",
    "Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria.",
    "Department of Rheumatology, Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK.",
    "School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.",
    "Department of Rheumatology, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Science Centre, Salford, UK.",
    "Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Kastriot Kastrati",
      "orcid": "0000-0002-1393-3390"
    },
    {
      "affs": [
        2
      ],
      "name": "Svitlana Pochepnia"
    },
    {
      "affs": [
        0
      ],
      "name": "Rade Drača"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Florian Prayer"
    },
    {
      "affs": [
        0
      ],
      "name": "Ece Danisman"
    },
    {
      "affs": [
        0
      ],
      "name": "Daniel Mrak"
    },
    {
      "affs": [
        4
      ],
      "name": "Thomas M Hofbauer"
    },
    {
      "affs": [
        0
      ],
      "name": "Daniel Aletaha"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Latika Gupta",
      "orcid": "0000-0003-2753-2990"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Hector Chinoy",
      "orcid": "0000-0001-6492-1288"
    },
    {
      "affs": [
        2
      ],
      "name": "Helmut Prosch",
      "orcid": "0000-0002-6119-6364"
    },
    {
      "affs": [
        0
      ],
      "name": "Helga Lechner-Radner",
      "orcid": "0000-0002-5908-1525"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cwrc62d6bcs4t.bib",
  "cited_by": 0,
  "doi": "10.1093/rheumatology/keag566",
  "fulltext_url": "https://europepmc.org/articles/PMC13707383",
  "id": "cwrc62d6bcs4t",
  "issns": [
    "1462-0324",
    "1462-0332"
  ],
  "landing_url": "https://europepmc.org/article/MED/42861766",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2741|Cardiac Imaging and Diagnostics"
    ]
  ],
  "openalex": "W7221533056",
  "pdf_url": "https://europepmc.org/articles/PMC13707383?pdf=render",
  "pmcid": "PMC13707383",
  "pmid": "42861766",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cwrc62d6bcs4t.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42861766",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42861766"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Cardiac Imaging and Diagnostics",
      "subfield": "imaging"
    }
  ],
  "title": "Cardiovascular risk stratification using chest CT in idiopathic inflammatory myopathies.",
  "title_text": "Cardiovascular risk stratification using chest CT in idiopathic inflammatory myopathies.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/cwrc62d6bcs4t",
  "venue": "Rheumatology (Oxford, England)",
  "versions": []
}