{
  "abstract": "The prognostic relevance of peritumoral SULF1 transcript signal in oral squamous cell carcinoma (OSCC) is unclear. We assembled a retrospective cohort of 133 patients with 218 primary-site tissue-microarray cores; 131 patients had evaluable boundary features. Multiplex fluorescence imaging combined RNAscope SULF1, CK-pan, and DAPI. Tumor-stroma boundaries were annotated with the SULF1 channel hidden. We screened 50 exported boundary features across cumulative stromal bands of 35-300 m against recurrence-free survival (RFS), overall survival (OS), and disease-specific survival (DSS), with false-discovery-rate correction. The strongest DSS association was signal SD within 150 m (n = 107; 23 disease-specific deaths; HR = 2.20 per SD; 95% CI, 1.64-2.94; q = 2.1 x 10-). In 50 repeated 5-fold cross-validations with feature selection repeated within training folds, adding a boundary feature to AJCC stage increased mean held-out DSS c-index from 0.613 to 0.754 ({Delta}C = +0.141; 2.5th-97.5th percentiles across repeats, +0.105 to +0.192). These percentiles describe split variability, not confidence intervals. The 150-m SD feature was selected in 39.2% of DSS training folds. The DSS association persisted after adjustment for mean signal, although the measurements were strongly correlated. Peritumoral SULF1 signal dispersion was associated with outcome beyond an ordinal AJCC-stage model; independent validation is required.",
  "abstract_shown": true,
  "affiliations": [
    "Georgetown University Medical Center"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "G. Furletti"
    },
    {
      "name": "T. C. Guerrero"
    },
    {
      "name": "E. Schrom"
    },
    {
      "name": "B. Davidson"
    },
    {
      "name": "B. Kallakury"
    },
    {
      "affs": [
        0
      ],
      "name": "R. Goldman"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cwwxcses7kjf5.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.09.26364914",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.10.09.26364914v1.full",
  "id": "cwwxcses7kjf5",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.10.09.26364914v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "pathology"
    ],
    [
      "openalex",
      "2733|Head and Neck Cancer Studies"
    ]
  ],
  "openalex": "W7221574444",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.10.09.26364914v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cwwxcses7kjf5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:42Z",
      "native_id": "10.64898/2026.10.09.26364914",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.10.09.26364914v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:pathology",
      "subfield": "general"
    }
  ],
  "title": "Peritumoral SULF1 Transcript Signal Is Associated with Disease-Specific Survival in Oral Squamous Cell Carcinoma",
  "title_text": "Peritumoral SULF1 Transcript Signal Is Associated with Disease-Specific Survival in Oral Squamous Cell Carcinoma",
  "type": "preprint",
  "updated_at": "2026-10-30T12:20:42Z",
  "url": "https://research.draconitic.com/paper/cwwxcses7kjf5",
  "venue": "medRxiv",
  "versions": []
}