{
  "abstract": "Psychedelic drugs exert rapid and profound effects on human consciousness [1-7] and are increasingly being investigated for their therapeutic potential [8-14]. Yet the transcriptional programs through which they may reshape brain function and structure remain incompletely understood, in part because the available evidence is heterogeneous and largely preclinical [15, 16]. In a structured scoping review of transcriptomic studies in animal models and neural cell cultures, we identified genes reported in the source literature to change within 3 h of classical psychedelic administration and intersected them with the Allen Human Brain Atlas to define an acute expression set. This retained set showed cortex-centered enrichment, a marker-based deep-layer projection-neuron component, and ontology enrichment for neuron projection and related synaptic terms. A smaller subset overlapped with human accelerated region-associated genes and showed greater-than-random spatial alignment with a human cortical-expansion map. The retained cortical-expression maps showed serotonergic spatial alignment in the human cortex, most prominently with HTR2A expression. Clustering identified three cortical spatial-expression modules, including an association/limbic-weighted module enriched for plasticity and synaptic-organization terms. Together, these findings provide a human cortical framework linking acute psychedelic-responsive transcription to cortical cell-type enrichment, HTR2A spatial expression, cortical spatial-expression modules, and cortical-expansion, while leaving receptor-specific, causal, translational, and cell-type-resolved mechanisms for future work.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.",
    "Department of Neurology, University of California, San Francisco, CA, USA.",
    "Department of Neurology, University of California, San Francisco, CA, USA. lorenzo.pasquini@ucsf.edu."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Patrick A McConnell"
    },
    {
      "affs": [
        1
      ],
      "name": "Jackson Raffety"
    },
    {
      "affs": [
        1
      ],
      "name": "Andrew Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Eric Steinberg"
    },
    {
      "affs": [
        1
      ],
      "name": "Syed Rahim"
    },
    {
      "affs": [
        1
      ],
      "name": "Christian Valtierra"
    },
    {
      "affs": [
        1
      ],
      "name": "Adam Gazzaley"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Robin L Carhart-Harris"
    },
    {
      "affs": [
        2
      ],
      "name": "Lorenzo Pasquini",
      "orcid": "0000-0002-7899-7061"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cwycmw9c3hbb2.bib",
  "cited_by": 0,
  "doi": "10.1038/s41398-026-04349-z",
  "fulltext_url": "https://europepmc.org/articles/PMC13720183",
  "id": "cwycmw9c3hbb2",
  "issns": [
    "2158-3188"
  ],
  "landing_url": "https://europepmc.org/article/MED/42957634",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "lcc",
      "RC321-571"
    ],
    [
      "openalex",
      "3203|Psychedelics and Drug Studies"
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  "openalex": "W7172134305",
  "pdf_url": "https://europepmc.org/articles/PMC13720183?pdf=render",
  "pmcid": "PMC13720183",
  "pmid": "42957634",
  "published": "2026-08-01",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/cwycmw9c3hbb2.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:47Z",
      "native_id": "MED:42957634",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42957634"
    },
    {
      "first_seen": "2026-11-01T14:21:25Z",
      "native_id": "0d61088694e1407c9f1c2a272817c56e",
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      "url": "https://doi.org/10.1038/s41398-026-04349-z"
    },
    {
      "first_seen": "2026-11-02T12:24:01Z",
      "native_id": "PMC13720183",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41398-026-04349-z"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3203|Psychedelics and Drug Studies",
      "subfield": "psychiatry"
    }
  ],
  "title": "Cross-species mapping of acute psychedelic-responsive genes links HTR2A cortical expression, cell-type enrichment, and human cortical expression modules.",
  "title_text": "Cross-species mapping of acute psychedelic-responsive genes links HTR2A cortical expression, cell-type enrichment, and human cortical expression modules.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T14:20:52Z",
  "url": "https://research.draconitic.com/paper/cwycmw9c3hbb2",
  "venue": "Translational psychiatry",
  "versions": []
}