{
  "abstract": "The decline of glomerular filtration is a hallmark of aging. Methylglyoxal (MG) is a uremic toxin known to induce aging-like changes; however, whether its mechanism of action is similar remains unclear. We compare the underlying mechanisms of MG and aging using Drosophila nephrocytes as a model. In addition to lower body weight, reduced locomotion, and shorter lifespans, MG caused filtration defects and induced cellular senescence in nephrocytes similar to the effects of aging, with a corresponding upregulation of the LXR/RXR signaling pathway. Mechanistically, we found that MG and aging both increased reactive oxygen species (ROS). Antioxidant treatments and inhibition of the LXR/RXR pathway both improved the filtration function. In addition, MG and aging both reduced the level of Jub, which is a protein essential for the integrity of the slit diaphragm structure. Overexpressing jub enhanced slit diaphragm structure and prevented MG-induced functional decline. Together, the findings reveal parallel features between MG and aging, and show that inhibiting LXR/RXR signaling, reducing ROS, or strengthening the slit diaphragm structure can preserve the filtration function of Drosophila nephrocytes.",
  "abstract_shown": true,
  "affiliations": [
    "Graduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan",
    "Present Address: Graduate Program of Nutrition Science, School of Life Science, National Taiwan Normal University, Taipei, Taiwan",
    "Renal Division, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan",
    "Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore",
    "Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan",
    "Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Lie Cheng"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Wan-Ju Yeh"
    },
    {
      "affs": [
        2
      ],
      "name": "Fan-Chi Chang"
    },
    {
      "affs": [
        3
      ],
      "name": "Hong-Wen Tang"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Chih-Chiang Chan"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Shuei-Liong Lin"
    },
    {
      "affs": [
        5
      ],
      "name": "Shu-Yi Huang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cx5c5bwj13w6z.bib",
  "cited_by": 0,
  "doi": "10.1038/s41514-026-00369-7",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737105/",
  "id": "cx5c5bwj13w6z",
  "issns": [
    "2731-6068"
  ],
  "landing_url": "https://doi.org/10.1038/s41514-026-00369-7",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1302|Genetics, Aging, and Longevity in Model Organisms"
    ]
  ],
  "openalex": "W7163545239",
  "pdf_url": "https://www.nature.com/articles/s41514-026-00369-7_reference.pdf",
  "pmcid": "PMC13737105",
  "pmid": "42243135",
  "published": "2026-06-04",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/cx5c5bwj13w6z.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:24Z",
      "native_id": "PMC13737105",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41514-026-00369-7"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1302|Genetics, Aging, and Longevity in Model Organisms",
      "subfield": "cell-biology"
    }
  ],
  "title": "Methylglyoxal engages aging-associated mechanisms to cause filtration impairment in nephrocytes",
  "title_text": "Methylglyoxal engages aging-associated mechanisms to cause filtration impairment in nephrocytes",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:24Z",
  "url": "https://research.draconitic.com/paper/cx5c5bwj13w6z",
  "venue": "NPJ Aging",
  "versions": []
}