{
  "abstract": "Objective\n\nThe concept of the gut-joint axis is often mentioned when exploring the pathogenesis of Ankylosing spondylitis (AS). This study aims to explore whether there is a causal association between Celiac disease (CeD) and AS.Method\n\nTwo-sample Mendelian randomization (MR) analysis was conducted using the CeD dataset (the largest pure CeD phenotype dataset in the IEU OpenGWAS database at the time of data retrieval, n = 24,269) and the AS dataset (strictly defined, from the IEU OpenGWAS database, n = 218,030). Inverse Variance Weighting (IVW) was adopted as the primary MR analysis method, supplemented by Weighted Median Estimator, MR-Egger regression, Simple Mode, and Weighted Mode to comprehensively evaluate the causal association between CeD and AS. Additionally, horizontal pleiotropy, heterogeneity, and leave-one-out analysis were performed to further evaluate the robustness and reliability of the results.Results\n\nIVW analysis showed a positive causal effect of genetically predicted CeD on AS (OR: 1.435, 95% CI: 1.210-1.702, p = 3.34E-05), and the other four analytical methods also yielded consistent causal effect evaluation results. No significant horizontal pleiotropy or heterogeneity was observed in this study.Conclusion\n\nMR analysis indicates that CeD may be a potential risk factor for AS, providing genetic evidence for the increased risk of AS in individuals with a genetic predisposition to CeD.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Basic Medical Sciences, Qinghai University Medical College, Xining, Qinghai, 810016, China. 1948407@qq.com.",
    "Department of Basic Medical Sciences, Qinghai University Medical College, Xining, Qinghai, 810016, China. qhugx@qq.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Meiqi Chen",
      "orcid": "0009-0009-2396-6688"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiang Gao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cx9qxm3wbdprf.bib",
  "cited_by": 0,
  "doi": "10.1186/s41927-026-00679-z",
  "fulltext_url": "https://europepmc.org/articles/PMC13678970",
  "id": "cx9qxm3wbdprf",
  "issns": [
    "2520-1026"
  ],
  "landing_url": "https://europepmc.org/article/MED/42897623",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC925-935"
    ],
    [
      "openalex",
      "2745|Spondyloarthritis Studies and Treatments"
    ]
  ],
  "openalex": "W7171948852",
  "pdf_url": "https://europepmc.org/articles/PMC13678970?pdf=render",
  "pmcid": "PMC13678970",
  "pmid": "42897623",
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/cx9qxm3wbdprf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:41Z",
      "native_id": "MED:42897623",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42897623"
    },
    {
      "first_seen": "2026-10-30T13:46:34Z",
      "native_id": "77f3addc3642424e86b542ac89bf9de3",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s41927-026-00679-z"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2745|Spondyloarthritis Studies and Treatments",
      "subfield": "general"
    }
  ],
  "title": "The causal association between Celiac disease and Ankylosing spondylitis: a two-sample Mendelian randomization analysis.",
  "title_text": "The causal association between Celiac disease and Ankylosing spondylitis: a two-sample Mendelian randomization analysis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:34Z",
  "url": "https://research.draconitic.com/paper/cx9qxm3wbdprf",
  "venue": "BMC rheumatology",
  "versions": []
}