{
  "abstract": "Aurones are naturally occurring flavonoids characterized by a benzofuran-3(2H)-one scaffold bearing an exocyclic benzylidene double bond. Herein, we report the synthesis and NMR-based structural characterization of a highly oxygenated biphenyl-bridged bis-aurone and its mono-condensation derivative. UV irradiation at 254 nm in deuterated acetone generated the corresponding E-containing photoisomers, whose formation was monitored by 1H NMR spectroscopy. For the bis-aurone, weak additional resonances indicated a minor species possibly corresponding to the doubly isomerized (E,E′) form. NOESY correlations provide constraints on the spatial arrangement of the bis-aurone in solution. Both isolated E-containing derivatives exhibit a pronounced downfield shift of one biphenyl aromatic proton. Conformational analysis is used to examine possible geometrical and magnetic-anisotropy contributions to this observation. The study focuses on synthesis, NMR observations of Z/E photoisomerization, and conformational interpretation; intrinsic photochemical efficiencies were not determined.",
  "abstract_shown": true,
  "affiliations": [
    "Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Traversa La Crucca 3, I–07100 Sassari, Italy"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Maria Antonietta Dettori",
      "orcid": "0000-0002-8776-9271"
    },
    {
      "affs": [
        0
      ],
      "name": "Davide Fabbri",
      "orcid": "0000-0002-3947-5164"
    },
    {
      "affs": [
        0
      ],
      "name": "Roberto Dallocchio"
    },
    {
      "affs": [
        0
      ],
      "name": "Nicola Culeddu",
      "orcid": "0000-0001-7432-6415"
    },
    {
      "affs": [
        0
      ],
      "name": "Emanuela Azara",
      "orcid": "0000-0001-9199-9398"
    },
    {
      "affs": [
        0
      ],
      "name": "Paola Carta",
      "orcid": "0000-0001-8749-6093"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cxjf969qas9vv.bib",
  "cited_by": 0,
  "doi": "10.3390/molecules31213963",
  "fulltext_url": null,
  "id": "cxjf969qas9vv",
  "issns": [
    "1420-3049"
  ],
  "landing_url": "https://www.mdpi.com/1420-3049/31/21/3963",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-03",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/cxjf969qas9vv.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T00:24:01Z",
      "native_id": "10.3390/molecules31213963",
      "source": "crossref",
      "url": "https://www.mdpi.com/1420-3049/31/21/3963"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "issn:1420-3049",
      "subfield": "general"
    }
  ],
  "title": "A C2-Symmetric Biphenyl-Bridged Bis-Aurone: Synthesis, Z/E Photoisomerization, and Conformational Insights from NMR Spectroscopy and DFT Analysis",
  "title_text": "A C2-Symmetric Biphenyl-Bridged Bis-Aurone: Synthesis, Z/E Photoisomerization, and Conformational Insights from NMR Spectroscopy and DFT Analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T00:20:53Z",
  "url": "https://research.draconitic.com/paper/cxjf969qas9vv",
  "venue": "Molecules",
  "versions": []
}