{
  "abstract": "Background: Several intraneuronal antibodies have been identified in association with paraneoplastic encephalitis, including anti-Ma and anti-Yo antibodies. There is a pure case of narcolepsy associated with anti-Ma2 antibody positivity with concomitant anti-Yo antibody.\n\nCase presentation: We report a 42-year-old male patient who presented with recurrent cataplexy as the primary and dominant symptom without typical hyperphagia in the early stages of narcolepsy associated with anti-Ma2 antibody positivity. Despite extensive screening, no underlying malignancy was detected over a 3-year disease duration. The patient exhibited significant clinical improvement following immunotherapy at the beginning.\n\nConclusions: This is a rare report of an isolated clinical manifestation of narcolepsy associated with anti-Ma2 antibody positivity with concomitant anti-Yo antibody. This case reminds clinicians to notice that cataplexy could be the only early symptom of narcolepsy associated with anti-Ma2 antibody positivity with concomitant anti-Yo antibody, which can easily lead to misdiagnoses. Autoimmune mechanisms may play an important role in the pathogenesis of narcolepsy associated with anti-Ma2 antibody positivity, and prompt immunotherapy offers a promising approach for its management.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, Xiangya Hospital, Central South University",
    "Department of Neurology, Fifth Affiliated Hospital of Sun Yat-Sen University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yefan Lv"
    },
    {
      "affs": [
        0
      ],
      "name": "Hui Lv"
    },
    {
      "affs": [
        0
      ],
      "name": "Yike Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaoyan Long"
    },
    {
      "affs": [
        1
      ],
      "name": "Jinxia Zhou"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cxmr8xpd3xd8a.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1942979",
  "fulltext_url": "https://europepmc.org/articles/PMC13677828",
  "id": "cxmr8xpd3xd8a",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1942979/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2728|Autoimmune Neurological Disorders and Treatments"
    ]
  ],
  "openalex": "W7220390643",
  "pdf_url": "https://europepmc.org/articles/PMC13677828?pdf=render",
  "pmcid": "PMC13677828",
  "pmid": "42898318",
  "published": "2026-10-05",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/cxmr8xpd3xd8a.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:15Z",
      "native_id": "10.3389/fimmu.2026.1942979",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1942979/full"
    },
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42898318",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898318"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Autoimmune Neurological Disorders and Treatments",
      "subfield": "neurology"
    }
  ],
  "title": "Case Report: Narcolepsy associated with anti-Ma2 antibody positivity",
  "title_text": "Case Report: Narcolepsy associated with anti-Ma2 antibody positivity",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:37Z",
  "url": "https://research.draconitic.com/paper/cxmr8xpd3xd8a",
  "venue": "Frontiers in Immunology",
  "versions": []
}