{
  "abstract": "Objective: Neudesin has been linked to adipose tissue activity, glucose metabolism, and insulin resistance. Evidence on its behavior in diabetic pregnancies is limited, particularly in women with pregestational type 2 diabetes mellitus (PREGDM). This exploratory cross-sectional controlled study evaluated serum neudesin concentrations in pregnancies complicated by pregestational type 2 diabetes mellitus (PREGDM) or gestational diabetes mellitus (GDM), and in non-diabetic pregnant controls without major systemic disease, while examining the influence of gestational timing.\n\nMethods: This study included 90 pregnant women: 30 with PREGDM, 30 with GDM, and 30 non-diabetic controls without major systemic disease. Controls were recruited in two planned gestational-age strata, including early pregnancy and 24–28 weeks, to provide clinically relevant timing-aware comparisons. Serum neudesin concentrations were measured using a human neudesin enzyme-linked immunosorbent assay kit (BT LAB, catalogue no. E4258Hu) and reported as ng/mL. Overall group comparisons were supplemented by gestational-timing-aware analyses and exploratory multivariable log-neudesin regression.\n\nResults: Overall median serum neudesin was highest in the PREGDM group (5.67 [4.72–6.21] ng/mL), followed by the GDM group (2.80 [2.70–3.10] ng/mL) and controls (2.17 [1.77–2.89] ng/mL; p < 0.001). In gestational-timing-aware comparisons, PREGDM remained higher than early-pregnancy controls (5.67 [4.72–6.21] vs. 1.70 [1.37–2.15] ng/mL; Hodges–Lehmann difference, 3.70 ng/mL; 95% CI, 3.15–4.35; p < 0.001). In contrast, GDM did not differ from controls sampled at 24–28 weeks (2.80 [2.70–3.10] vs. 2.85 [2.28–3.03] ng/mL; Hodges–Lehmann difference, 0.04 ng/mL; 95% CI, − 0.20 to 0.40; p = 0.791). In the diabetic-only model adjusted for gestational age and age, the PREGDM-GDM contrast was attenuated (GMR, 1.31; 95% CI, 0.61–2.85; p = 0.490). In the all-participant adjusted model, PREGDM remained associated with higher neudesin than controls (GMR, 3.11; 95% CI, 2.57–3.76; p < 0.001), whereas the GDM-control contrast was not significant (GMR, 1.12; 95% CI, 0.96–1.30; p = 0.149).\n\nConclusion: Serum neudesin was most consistently elevated in pregnancies complicated by PREGDM. The apparent overall GDM-control difference was not retained after timing-aware comparison or adjustment. Given the modest sample size, neudesin should be considered an exploratory complementary metabolic marker rather than a standalone diagnostic biomarker.",
  "abstract_shown": true,
  "affiliations": [
    "Ankara Etlik City Hospital Internal Medicine, Ankara, Turkey",
    "Ankara Etlik City Hospital Medical Biochemistry, Ankara, Turkey"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zuhal Köksal",
      "orcid": "0000-0002-3562-9859"
    },
    {
      "affs": [
        1
      ],
      "name": "Funda Güçel"
    },
    {
      "affs": [
        0
      ],
      "name": "Şeyma Sarışen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cxn83m4b0s5b1.bib",
  "cited_by": 0,
  "doi": "10.1186/s12884-026-09743-5",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13715164/",
  "id": "cxn83m4b0s5b1",
  "issns": [
    "1471-2393"
  ],
  "landing_url": "https://doi.org/10.1186/s12884-026-09743-5",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2729|Gestational Diabetes Research and Management"
    ]
  ],
  "openalex": "W7172002845",
  "pdf_url": null,
  "pmcid": "PMC13715164",
  "pmid": "42947056",
  "published": "2026-07-31",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/cxn83m4b0s5b1.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:22:31Z",
      "native_id": "PMC13715164",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12884-026-09743-5"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2729|Gestational Diabetes Research and Management",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Serum neudesin is elevated in pregnancies complicated by pregestational type 2 diabetes: an exploratory cross-sectional controlled study",
  "title_text": "Serum neudesin is elevated in pregnancies complicated by pregestational type 2 diabetes: an exploratory cross-sectional controlled study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:31Z",
  "url": "https://research.draconitic.com/paper/cxn83m4b0s5b1",
  "venue": "BMC Pregnancy and Childbirth",
  "versions": []
}