{
  "abstract": "Background: Pleural mesothelioma (PM) is an aggressive malignancy with considerable biological heterogeneity and few established prognostic biomarkers. We evaluated the clinicopathological and prognostic relevance of B7-H3, TROP2, and p16 expression in PM. Methods: This retrospective study included 50 patients with histologically confirmed PM diagnosed between 2016 and 2025. Immunohistochemical expression of B7-H3, TROP2, and p16 was evaluated using an immunoreactivity scoring system. Associations with clinicopathological features were examined, and overall survival (OS) and progression-free survival (PFS) were analyzed using Kaplan–Meier and Cox proportional hazards methods. Results: High B7-H3, TROP2, and p16 expression was observed in 78%, 18%, and 20% of tumors, respectively. High B7-H3 expression was significantly associated with asbestos exposure, chemotherapy, and tumor stage. Patients with high B7-H3 expression had shorter median OS (11.0 vs. 42.0 months; p < 0.001) and PFS (11.0 vs. 40.0 months; p = 0.004) than those with negative/low expression. Neither TROP2 nor p16 expression was significantly associated with survival. In a parsimonious multivariable Cox model, high B7-H3 expression remained significantly associated with poorer OS after adjustment for disease stage (HR = 4.42, 95% CI: 1.29–15.21, p = 0.018). Conclusions: B7-H3 is frequently expressed in PM and was associated with poorer survival, including after adjustment for disease stage. These findings support further investigation of B7-H3 as a potential prognostic biomarker and therapeutic target in PM.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pulmonology, Faculty of Medicine, Sivas Cumhuriyet University, 58140 Sivas, Turkey",
    "Department of Pathology, Faculty of Medicine, Sivas Cumhuriyet University, 58140 Sivas, Turkey",
    "Department of Thoracic Surgery, Faculty of Medicine, Sivas Cumhuriyet University, 58140 Sivas, Turkey"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Neslihan Tas",
      "orcid": "0000-0002-8905-1896"
    },
    {
      "affs": [
        1
      ],
      "name": "Ramazan Oguz Yüceer",
      "orcid": "0000-0002-9418-8862"
    },
    {
      "affs": [
        1
      ],
      "name": "Tulay Koc",
      "orcid": "0000-0001-8612-0238"
    },
    {
      "affs": [
        0
      ],
      "name": "Yusuf Sönmez"
    },
    {
      "affs": [
        2
      ],
      "name": "Hasan Dogan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cxpaydmgq3yrx.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15207998",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705769/?tool=EBI",
  "id": "cxpaydmgq3yrx",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/20/7998",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Occupational and environmental lung diseases"
    ]
  ],
  "openalex": "W7222310048",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705769/pdf/?tool=EBI",
  "pmcid": "PMC13705769",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/cxpaydmgq3yrx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:00Z",
      "native_id": "10.3390/jcm15207998",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/20/7998"
    },
    {
      "first_seen": "2026-10-30T12:21:47Z",
      "native_id": "PMC:PMC13705769",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13705769"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Occupational and environmental lung diseases",
      "subfield": "general"
    }
  ],
  "title": "Prognostic Significance of B7-H3, TROP2, and p16 Expression in Pleural Mesothelioma: Clinicopathological Correlations and Survival Outcomes",
  "title_text": "Prognostic Significance of B7-H3, TROP2, and p16 Expression in Pleural Mesothelioma: Clinicopathological Correlations and Survival Outcomes",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:47Z",
  "url": "https://research.draconitic.com/paper/cxpaydmgq3yrx",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}