{
  "abstract": "Objective: To investigate the levels of family functioning, resilience, and symptom experience in kidney transplant recipients, and to examine the mediating role of resilience in the relationship between family functioning and symptom experience. Methods: A cross-sectional study was conducted from January to February 2025. A convenience sample of 333 kidney transplant recipients was recruited from a tertiary hospital in Wuhan, China. Participants completed the Chinese Version of the Resilience Scale for Kidney Transplantation, the Organ Transplant Symptom and Well-being Inventory, and the Family APGAR Index. Data were analyzed using correlation, hierarchical regression, and bootstrap mediation tests. Results: Participants reported a moderate level of symptom burden (OTSWI total score: 46.56 ± 23.86). Both resilience (r = –0.222, p < .01) and family functioning (r = –0.202, p < .01) were significantly correlated with lower symptom burden. After controlling for demographic and clinical variables, resilience (β = −0.152, p = .005) and family functioning (β = −0.124, p = .022) remained independent predictors. Mediation analysis showed that resilience was consistent with a partial mediating role in the relationship between family functioning and symptom experience, accounting for 18.4% of the total effect (indirect effect = –0.326, 95% BCa CI [–0.645, –0.081]). Conclusion: The findings are consistent with resilience partially mediating the association between family functioning and symptom experience in kidney transplant recipients. Assessing both family support and psychological resilience may help identify high-risk patients and inform integrated interventions aimed at alleviating symptom burden.Given the cross-sectional design, causal inference cannot be established.",
  "abstract_shown": true,
  "affiliations": [
    "Hemodialysis Center, The Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University, Wuhan, Hubei, China",
    "The Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan, Hubei, China",
    "The Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China",
    "Nursing Department, Renmin Hospital of Wuhan University, Wuhan, Hubei, China"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
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        0
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      "name": "Yan Tang"
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    {
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        1
      ],
      "name": "Jiefu Zhu"
    },
    {
      "affs": [
        2
      ],
      "name": "Jinke Li"
    },
    {
      "affs": [
        3
      ],
      "name": "Jiangqiao Zhou"
    },
    {
      "name": "Rong Wang"
    },
    {
      "name": "Tao Qiu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cxpbphaeehwdy.bib",
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  "doi": "10.1371/journal.pone.0361968",
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  "id": "cxpbphaeehwdy",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0361968",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "plos",
      "/Biology and life sciences/Neuroscience/Cognitive science/Cognitive psychology/Clinical psychology"
    ],
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      "/Biology and life sciences/Psychology/Cognitive psychology/Clinical psychology"
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      "/Medicine and health sciences/Surgical and invasive medical procedures/Transplantation/Organ transplantation/Renal transplantation"
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      "/Medicine and health sciences/Surgical and invasive medical procedures/Urinary system procedures/Renal transplantation"
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      "/Research and analysis methods/Research design/Cross-sectional studies"
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      "/Social sciences/Psychology/Psychological stress"
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  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-12",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/cxpbphaeehwdy.ris",
  "sources": [
    {
      "first_seen": "2026-11-13T12:20:02Z",
      "native_id": "10.1371/journal.pone.0361968",
      "source": "plos",
      "url": "https://doi.org/10.1371/journal.pone.0361968"
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  "subjects": [
    {
      "field": "mathematics",
      "origin": "plos:statistical methods",
      "subfield": "statistics"
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    {
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      "origin": "plos:clinical psychology",
      "subfield": "psychiatry"
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    {
      "field": "medicine",
      "origin": "plos:surgical and invasive medical procedures",
      "subfield": "surgery"
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  "title": "Resilience and its mediating role in the association between family functioning and symptom experience in kidney transplant recipients: A cross-sectional study",
  "title_text": "Resilience and its mediating role in the association between family functioning and symptom experience in kidney transplant recipients: A cross-sectional study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-14T12:20:46Z",
  "url": "https://research.draconitic.com/paper/cxpbphaeehwdy",
  "venue": "PLOS One",
  "versions": []
}