{
  "abstract": "The use of diboron compounds for nitro group reduction, an essential transformation in the synthesis of a wide range of nitrogen-containing functional groups, offers an attractive alternative to traditional methods like hydrogenation and dissolving metal reduction. This method has seen limited uptake in the literature despite avoiding transition metals and specialized equipment. Using a combination of reaction calorimetry and kinetic analysis, careful selection of the reaction solvent, diboron source, and inclusion of water enabled the identification of safe and simple conditions for reduction of nitro groups. The scope of the reaction is broad under mild conditions where water plays a critical role in driving reactivity while maintaining wide safety margins.",
  "abstract_shown": true,
  "affiliations": [
    "Chemical Process Development, Bristol Myers Squibb, 1 Squibb Drive, New Brunswick, NJ, United States, 08903",
    "Bristol Myers Squibb Therapeutic Discovery Sciences, P.O. Box 4000, Princeton, New Jersey, 08543"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yilin Cao"
    },
    {
      "affs": [
        0
      ],
      "name": "Matthew Joannou"
    },
    {
      "affs": [
        1
      ],
      "name": "Michael Mandler"
    },
    {
      "affs": [
        0
      ],
      "name": "Sergey Melnikov"
    },
    {
      "affs": [
        1
      ],
      "name": "Iulia Teleuca"
    },
    {
      "affs": [
        0
      ],
      "name": "Shasha Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Gregory Beutner",
      "orcid": "0000-0001-8779-1404"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cy4yyx1a1cf7v.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15009744/v1",
  "fulltext_url": null,
  "id": "cy4yyx1a1cf7v",
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  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009744/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Organoboron and organosilicon chemistry"
    ]
  ],
  "openalex": "W7215031543",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009744/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/cy4yyx1a1cf7v.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:21Z",
      "native_id": "10.26434/chemrxiv.15009744",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009744/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Organoboron and organosilicon chemistry",
      "subfield": "organic"
    }
  ],
  "title": "The Critical Role of Water in Safe, Scalable Diboron-Mediated Nitro Reductions .",
  "title_text": "The Critical Role of Water in Safe, Scalable Diboron-Mediated Nitro Reductions .",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:21Z",
  "url": "https://research.draconitic.com/paper/cy4yyx1a1cf7v",
  "venue": "ChemRxiv",
  "versions": []
}