{ "abstract": "Introduction\n\nReal-world epidemiological and longitudinal outcome data on autosomal dominant polycystic kidney disease (ADPKD) remain limited in underrepresented populations, including Türkiye. We aimed to characterize the epidemiology, regional distribution, and renal outcomes of ADPKD in a large multicenter national cohort.Methods\n\nIn this retrospective multicenter study, adult patients with ADPKD were identified across tertiary nephrology centers in six regions of Türkiye (2010-2025). Study-based prevalence was calculated using Turkish Statistical Institute population data. Longitudinal renal outcomes were evaluated using serial eGFR measurements and Cox regression models identified predictors of ≥ 40% eGFR decline.Results\n\nA total of 2361 patients were included (mean age 38.6 ± 14 years; 51.8% female). Median province-level study-based prevalence was 3.86 per 100,000 population (IQR 2.92-5.49), with substantial regional variation, highest in the Black Sea region (13.46 per 100,000). Study-based prevalence increased significantly over time (annual percent change 14.4%; 95% CI 13.1-15.6; p < 0.001). During a median follow-up of 6 years, 23.9% experienced a ≥ 40% eGFR decline and 10.5% progressed to kidney failure (eGFR < 15 ml/min/1.73m2). Median annual eGFR decline was - 3.33 mL/min/1.73 m²/year. In multivariable analysis, age (adjusted HR 1.02; 95% CI 1.00-1.03; p = 0.010) and hypertension (adjusted HR 2.33; 95% CI 1.25-4.32; p = 0.007) were independently associated with renal progression, whereas tolvaptan use was associated with a lower risk of progression (adjusted HR 0.56; 95% CI 0.37-0.85; p = 0.004). The Mayo Imaging Classification remained independently predictive of renal outcomes (p = 0.027).Conclusions\n\nThis large real-world multicenter cohort highlights the geographically heterogeneous study-based burden of ADPKD across participating regions of Türkiye. Increasing prevalence over time likely reflects improved disease recognition, whereas the relatively low study-based prevalence suggests persistent under-recognition of ADPKD. These findings provide important longitudinal outcome data from an underrepresented population and support the need for earlier detection and improved risk stratification in ADPKD.", "abstract_shown": true, "affiliations": [ "Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Dokuz Eylul University, İzmir, Türkiye. serpilmuge.deger@deu.edu.tr.", "Division of Nephrology, Department of Internal Medicine, Kocaeli University Faculty of Medicine, Kocaeli, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Etlik City Hospital, Health Sciences University, Ankara, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Karadeniz Technical University, Trabzon, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Bursa Uludağ University, Bursa, Türkiye.", "Division of Nephrology, Department of Internal Medicine, İstanbul Medeniyet University Faculty of Medicine, İstanbul, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Göztepe Prof. Dr. Süleyman Yalçın City Hospital, Istanbul, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Akdeniz University Faculty of Medicine, Antalya, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Dokuz Eylul University, İzmir, Türkiye.", "Division of Nephrology, Department of Internal Medicine,Faculty of Medicine, Ankara Yıldırım Beyazıt University, Ankara, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Turkey.", "Division of Nephrology, Department of Internal Medicine, Kartal training hospital, Istanbul, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Trakya University, Tekirdag, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Mugla Sıtkı Kocman University, Mugla, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Gaziantep University Faculty of Medicine, Gaziantep, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Celal Bayar University Faculty of Medicine, Manisa, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Duzce University, Duzce, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, University of Health Sciences, Balikesir Ataturk Education and Research Hospital, Balıkesir, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Mersin University, Mersin, Türkiye.", "Division of Nephrology, Department of Internal Medicine,Faculty of Medicine, Pamukkale University, Denizli, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, University of Health Sciences, Afyonkarahisar Education and Research Hospital, Afyonkarahisar, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Giresun University Faculty of Medicine, Giresun, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Ankara University Faculty of Medicine, Ankara, Turkey.", "Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, İzmir City Hospital, Health Sciences University, İzmir, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Bagcilar Training and Research Hospital, University of Health Sciences, Istanbul, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Sakarya University Faculty of Medicine, Sakarya, Türkiye.", "Nephrology Clinic, Gazi Yaşargil Educational Research Hospital, Diyarbakır, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Basaksehir Çam ve Sakura City Hospital, Healty Sciences University, İstanbul, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Canakkale Onsekiz Mart University Faculty of Medicine, Çanakkale, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Cukurova University, Adana, Türkiye.", "Division of Nephrology, Department of Internal Medicine, Haydarpaşa Numune Training and Research Hospital, Healty Sciences University, İstanbul, Türkiye.", "Department of Nephrology, Liv Hospital Vadi Istanbul, İstanbul, Türkiye." ], "article_type": "research article", "arxiv": null, "author_total": 47, "authors": [ { "affs": [ 0 ], "name": "Serpil Muge Deger", "orcid": "0000-0002-7635-2382" }, { "affs": [ 1 ], "name": "Necmi Eren", "orcid": "0000-0002-2708-3470" }, { "affs": [ 2 ], "name": "Sibel Yucel Kocak", "orcid": "0000-0003-3984-4043" }, { "affs": [ 3 ], "name": "Gulay Ulusal Okyay", "orcid": "0000-0003-0770-1283" }, { "affs": [ 4 ], "name": "Beyhan Güvercin", "orcid": "0000-0003-4157-4513" }, { "affs": [ 5 ], "name": "Abdulmecit Yildiz", "orcid": "0000-0001-5941-9103" }, { "affs": [ 5 ], "name": "Halime Soyak Kabaca", "orcid": "0000-0003-3790-1059" }, { "affs": [ 6 ], "name": "Sabahat Alisir Ecder", "orcid": "0000-0003-2631-6532" }, { "affs": [ 7 ], "name": "Tahsin Karaaslan", "orcid": "0000-0002-1529-1790" }, { "affs": [ 8 ], "name": "Ayca Inci", "orcid": "0000-0002-7894-8913" }, { "affs": [ 9 ], "name": "Mehmet Asi Oktan", "orcid": "0000-0002-9322-5844" }, { "affs": [ 10 ], "name": "Mine Sebnem Karakan", "orcid": "0000-0002-7499-1738" }, { "affs": [ 11 ], "name": "Asil Demirezen", "orcid": "0009-0004-4449-8266" }, { "affs": [ 11 ], "name": "Ulver Boztepe Derici", "orcid": "0000-0002-9741-6779" }, { "affs": [ 12 ], "name": "Bartu Ediz", "orcid": "0009-0000-9588-4803" }, { "affs": [ 13 ], "name": "Ilhan Kurultak", "orcid": "0000-0001-5607-1375" }, { "affs": [ 14 ], "name": "Bulent Huddam", "orcid": "0000-0002-8412-1584" }, { "affs": [ 15 ], "name": "Ozlem Usalan", "orcid": "0000-0002-6339-8648" }, { "affs": [ 9 ], "name": "Ilker Atay", "orcid": "0009-0004-4558-2152" }, { "affs": [ 16 ], "name": "Aysun Toraman", "orcid": "0000-0003-2290-3342" }, { "affs": [ 17 ], "name": "Haci Hasan Yeter", "orcid": "0000-0002-5787-1048" }, { "affs": [ 18 ], "name": "Kursad Onec", "orcid": "0000-0003-3866-2838" }, { "affs": [ 19 ], "name": "Alper Azak", "orcid": "0000-0001-6228-8829" }, { "affs": [ 20 ], "name": "Kenan Turgutalp", "orcid": "0000-0003-0245-1844" }, { "affs": [ 21 ], "name": "Belda Dursun", "orcid": "0000-0003-3235-0577" }, { "affs": [ 22 ], "name": "Onur Tunca", "orcid": "0000-0003-1958-7617" }, { "affs": [ 22 ], "name": "Sinan Kazan", "orcid": "0000-0001-7290-4680" }, { "affs": [ 23 ], "name": "Tulin Akagun", "orcid": "0000-0003-2863-7882" }, { "affs": [ 24 ], "name": "Saliha Yıldırım", "orcid": "0000-0002-2693-1167" }, { "affs": [ 3 ], "name": "Emre Yasar", "orcid": "0000-0001-8271-1831" }, { "affs": [ 25 ], "name": "Hulya Colak", "orcid": "0000-0003-2867-6937" }, { "affs": [ 25 ], "name": "Hayri Ustun Arda", "orcid": "0000-0001-6471-3112" }, { "affs": [ 26 ], "name": "Selma Alagoz", "orcid": "0000-0001-5416-2257" }, { "affs": [ 27 ], "name": "Hamad Dheir", "orcid": "0000-0002-3569-6269" }, { "affs": [ 27 ], "name": "Musa Pinar", "orcid": "0000-0001-8164-6302" }, { "affs": [ 28 ], "name": "Ramazan Danis", "orcid": "0000-0001-7493-7179" }, { "affs": [ 28 ], "name": "Eren Eynel", "orcid": "0000-0002-2551-4767" }, { "affs": [ 29 ], "name": "Berna Yelken", "orcid": "0009-0000-9134-7541" }, { "affs": [ 29 ], "name": "Gursel Yildiz", "orcid": "0000-0002-2445-1477" }, { "affs": [ 8 ], "name": "Funda Sari", "orcid": "0000-0003-0128-3244" }, { "affs": [ 30 ], "name": "Serkan Bakirdogen", "orcid": "0000-0002-3448-0490" }, { "affs": [ 31 ], "name": "Bulent Kaya", "orcid": "0000-0003-4697-4815" }, { "affs": [ 32 ], "name": "Ozgur Can", "orcid": "0000-0001-8720-1400" }, { "affs": [ 32 ], "name": "Melike Betul Ogutmen", "orcid": "0000-0002-6623-9669" }, { "affs": [ 1 ], "name": "Metin Ergul", "orcid": "0000-0002-0706-6550" }, { "affs": [ 1 ], "name": "Sibel Gokcay Bek", "orcid": "0000-0003-3325-5993" }, { "affs": [ 33 ], "name": "Tevfik Ecder", "orcid": "0000-0003-3394-5775" } ], "bibtex": "https://research.draconitic.com/paper/cy8d5ty8dra9j.bib", "cited_by": 0, "doi": "10.1186/s12882-026-05217-0", "fulltext_url": "https://europepmc.org/articles/PMC13685119", "id": "cy8d5ty8dra9j", "issns": [ "1471-2369" ], "landing_url": "https://europepmc.org/article/MED/42902287", "language": "eng", "licence": "CC-BY", "licence_label": "CC BY", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by/4.0/", "metadata_licence": null, "native_subjects": [ [ "lcc", "RC870-923" ], [ "openalex", "1311|Genetic and Kidney Cyst Diseases" ] ], "openalex": "W7170749242", "pdf_url": "https://europepmc.org/articles/PMC13685119?pdf=render", "pmcid": "PMC13685119", "pmid": "42902287", "published": "2026-07-01", "publisher": "BMC", "ris": "https://research.draconitic.com/paper/cy8d5ty8dra9j.ris", "sources": [ { "first_seen": "2026-10-30T12:19:41Z", "native_id": "MED:42902287", "source": "europepmc", "url": "https://europepmc.org/article/MED/42902287" }, { "first_seen": "2026-10-30T13:45:42Z", "native_id": "3e81c2da20264d57b6254d7a78602c43", "source": "doaj", "url": "https://doi.org/10.1186/s12882-026-05217-0" } ], "subjects": [ { "field": "biology", "origin": "openalex:1311|Genetic and Kidney Cyst Diseases", "subfield": "genetics-genomics" } ], "title": "Real-world epidemiology and renal outcomes of ADPKD in Türkiye: the PKD-TURK cohort.", "title_text": "Real-world epidemiology and renal outcomes of ADPKD in Türkiye: the PKD-TURK cohort.", "type": "peer-reviewed", "updated_at": "2026-10-30T13:45:42Z", "url": "https://research.draconitic.com/paper/cy8d5ty8dra9j", "venue": "BMC nephrology", "versions": [] }