{
  "abstract": "Purpose/Objective(s): Recurrent and metastatic non-anaplastic thyroid cancer has traditionally been considered relatively radioresistant. We evaluated whether anatomic site or histology risk group better predicts local control (LC) following stereotactic radiation therapy (SBRT/SRS).\n\nMaterials/Methods: We retrospectively reviewed 32 patients with 66 treated lesions (42 skeletal, 24 non-skeletal) treated between 2012 and 2025. Histology was dichotomized into low-risk (papillary, follicular, medullary, Hürthle cell; n=61) and high-risk (poorly differentiated and squamous cell carcinoma; n=5). BED ₁₀ was calculated using α/β = 10 Gy. LC was defined per RECIST 1.1. Kaplan–Meier and log-rank tests were used. Intra-patient correlation was addressed via generalized estimating equations (GEE) and Cox shared frailty models. A multivariable GEE model included histology risk, site, BED ₁₀ , PTV volume, prior surgery, and age.\n\nResults: Median follow-up was 15.0 months. Six local failures occurred (crude LC 90.9%); 1- and 2-year LC were 96.5% and 87.1%. Histology risk was the dominant determinant: low-risk histology achieved 95.1% crude LC versus 40.0% for high-risk (log-rank p=0.002). In multivariable GEE analysis, low-risk histology was independently associated with LC (OR 158.0, 95% CI 1.72–14,479.7; p=0.028), whereas skeletal site was not (OR 1.07, 95% CI 0.02–51.8; p=0.974). BED ₁₀ was not associated with LC after adjustment (p=0.752). Skeletal and non-skeletal LC were similar after histology stratification (95.0% vs 95.2% among low-risk). Treatment was well tolerated; no Grade ≥3 radiation toxicity, myelopathy, or fractures occurred.\n\nConclusion: In stereotactic radiation for metastatic non-anaplastic thyroid cancer, histology risk grouping—not anatomic site or dose escalation—is the dominant predictor of local control. These findings support histology-based risk stratification for SRT patient selection.",
  "abstract_shown": true,
  "affiliations": [
    "Northwell Health , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Bin Gui"
    },
    {
      "affs": [
        0
      ],
      "name": "Jayavignesh Sekar"
    },
    {
      "affs": [
        0
      ],
      "name": "Margaret Locke"
    },
    {
      "affs": [
        0
      ],
      "name": "Shyamali Saha"
    },
    {
      "affs": [
        0
      ],
      "name": "Mitchell Tulchinsky"
    },
    {
      "affs": [
        0
      ],
      "name": "Brianna Jones"
    },
    {
      "affs": [
        0
      ],
      "name": "Nagashree Seetharamu"
    },
    {
      "affs": [
        0
      ],
      "name": "Maged Ghaly"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cya7phjvghb7h.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1898567",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661363/?tool=EBI",
  "id": "cya7phjvghb7h",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13661363",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2712|Thyroid Cancer Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7214943296",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661363/pdf/?tool=EBI",
  "pmcid": "PMC13661363",
  "pmid": null,
  "published": "2026-09-30",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/cya7phjvghb7h.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:21Z",
      "native_id": "PMC:PMC13661363",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13661363"
    },
    {
      "first_seen": "2026-10-30T12:20:13Z",
      "native_id": "10.3389/fonc.2026.1898567",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1898567/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2712|Thyroid Cancer Diagnosis and Treatment",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Local control after stereotactic radiation for thyroid cancer: a histology risk-stratified analysis",
  "title_text": "Local control after stereotactic radiation for thyroid cancer: a histology risk-stratified analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:13Z",
  "url": "https://research.draconitic.com/paper/cya7phjvghb7h",
  "venue": "Frontiers in oncology",
  "versions": []
}