{
  "abstract": "Mitral regurgitation is a highly prevalent valvular heart disease and, when hemodynamically significant, is associated with adverse outcomes. Despite advances in surgical techniques and catheter-based edge-to-edge repair, a large number of patients remain untreated due to high surgical risk or anatomical limitations. Transcatheter mitral valve replacement (TMVR) has emerged as a promising therapeutic option for these patients. Over the past 15 years, the TMVR field has substantially progressed, with multiple devices advancing to human clinical evaluation. This review aims to provide an overview of the key milestones in TMVR development, patient selection pathways, and the transition from transapical to transseptal delivery. We further summarize the available clinical outcomes across different platforms and discuss remaining knowledge gaps, as well as future directions for this evolving field.",
  "abstract_shown": true,
  "affiliations": [
    "Clinical Trials Center, Cardiovascular Research Foundation, New York, New York, USA.",
    "Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.",
    "Department of Clinical Physiology and Echocardiography-Heart Valve Clinic, CHU Lille, Lille, France.",
    "Department of Cardiology, Heart Center, Faculty of Medicine, University of Cologne, Cologne, Germany.",
    "Department of Interventional Cardiology, McGill University Health Centre, Montreal, Quebec, Canada.",
    "Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, USA.",
    "Cardiology Department, Interbalkan Medical Center, Thessaloniki, Greece.",
    "Interventional Cardiology, University of British Columbia, Vancouver, British Columbia, Canada.",
    "Interventional Cardiology, Sutter Health California Pacific Medical Center, San Francisco, California, USA.",
    "Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.",
    "Columbia University Medical Center, New York Presbyterian Hospital, New York, New York, USA.",
    "Medico-Surgical Department, Haut-Lévêque Cardiological Hospital; Bordeaux University Hospital, Pessac, France."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Guido Ascione",
      "orcid": "0000-0002-7727-0573"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Sebastian Ludwig",
      "orcid": "0000-0002-5752-4951"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Augustin Coisne"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Philipp von Stein"
    },
    {
      "affs": [
        4
      ],
      "name": "Nicolo Piazza"
    },
    {
      "affs": [
        5
      ],
      "name": "Firas Zahr"
    },
    {
      "affs": [
        6
      ],
      "name": "Vlasis Ninios"
    },
    {
      "affs": [
        7
      ],
      "name": "D Scott Lim"
    },
    {
      "affs": [
        8
      ],
      "name": "David V Daniels"
    },
    {
      "affs": [
        9
      ],
      "name": "Charanjit S Rihal"
    },
    {
      "affs": [
        0,
        10
      ],
      "name": "Torsten P Vahl"
    },
    {
      "affs": [
        11
      ],
      "name": "Thomas Modine"
    },
    {
      "affs": [
        0
      ],
      "name": "Juan F Granada"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cyegvke0wpchz.bib",
  "cited_by": 0,
  "doi": "10.1016/j.shj.2026.101125",
  "fulltext_url": "https://europepmc.org/articles/PMC13681998",
  "id": "cyegvke0wpchz",
  "issns": [
    "2474-8706",
    "2474-8714"
  ],
  "landing_url": "https://europepmc.org/article/MED/42903629",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2705|Cardiac Valve Diseases and Treatments"
    ]
  ],
  "openalex": "W7211895626",
  "pdf_url": "https://europepmc.org/articles/PMC13681998?pdf=render",
  "pmcid": "PMC13681998",
  "pmid": "42903629",
  "published": "2026-09-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cyegvke0wpchz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:57Z",
      "native_id": "MED:42903629",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42903629"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiac Valve Diseases and Treatments",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Transcatheter Mitral Valve Replacement: Clinical Challenges, Evolving Indications, and Future Directions.",
  "title_text": "Transcatheter Mitral Valve Replacement: Clinical Challenges, Evolving Indications, and Future Directions.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:57Z",
  "url": "https://research.draconitic.com/paper/cyegvke0wpchz",
  "venue": "Structural heart : the journal of the Heart Team",
  "versions": []
}