{
  "abstract": "The skin functions as a barrier against external insults and as an active immune organ. Keratinocytes are central to both roles, maintaining epidermal integrity while coordinating cutaneous immune responses. Necroptosis is a lytic form of regulated cell death that can compromise the epidermal barrier and release damage-associated molecular patterns, thereby linking tissue injury to immune activation. Accumulating evidence implicates keratinocyte necroptosis in multiple inflammatory skin diseases and acute epidermal injuries. This mini review summarizes the molecular regulation of keratinocyte necroptosis, critically appraises evidence for its involvement across distinct pathological contexts, and evaluates therapeutic strategies and associated translational challenges. Mechanistic studies and preliminary translational evidence suggest that necroptosis-related signaling in keratinocytes may represent a therapeutic target. However, the effects of pathway modulation may vary across disease contexts and depend on infection status and the immune microenvironment. Defining the disease-specific contribution of keratinocyte necroptosis and the corresponding therapeutic windows will therefore be essential for evaluating the clinical feasibility of this strategy.",
  "abstract_shown": true,
  "affiliations": [
    "The First Clinical College, Liaoning University of Traditional Chinese Medicine , ,",
    "Department of Rehabilitation, Children's Hospital of Shenyang City , ,",
    "Chongqing Three Gorges Medical College , ,",
    "Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University , ,",
    "Department of Infection Management Section, Shenyang First People's Hospital , ,",
    "The First Clinical College, Shenyang Medical University , ,",
    "Department of Endocrinology and Metabolic Diseases, Shenyang First People's Hospital , ,"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xu Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Di Qu"
    },
    {
      "affs": [
        2
      ],
      "name": "Jinyan Luo"
    },
    {
      "affs": [
        3
      ],
      "name": "Bo Chen"
    },
    {
      "affs": [
        4
      ],
      "name": "Xin Zhao"
    },
    {
      "affs": [
        5
      ],
      "name": "Zhengxu Fu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jingdong Wu"
    },
    {
      "affs": [
        2
      ],
      "name": "Fan Xia"
    },
    {
      "affs": [
        6
      ],
      "name": "Yan Yan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cym4dc1xrge8h.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1967855",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673654/?tool=EBI",
  "id": "cym4dc1xrge8h",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13673654",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Cell death mechanisms and regulation"
    ]
  ],
  "openalex": "W7216363584",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673654/pdf/?tool=EBI",
  "pmcid": "PMC13673654",
  "pmid": null,
  "published": "2026-10-02",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/cym4dc1xrge8h.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:18Z",
      "native_id": "PMC:PMC13673654",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13673654"
    },
    {
      "first_seen": "2026-10-30T12:19:15Z",
      "native_id": "10.3389/fimmu.2026.1967855",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1967855/full"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Cell death mechanisms and regulation",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Keratinocyte necroptosis in inflammatory skin diseases and acute epidermal injury: mechanisms, evidence, and therapeutic implications",
  "title_text": "Keratinocyte necroptosis in inflammatory skin diseases and acute epidermal injury: mechanisms, evidence, and therapeutic implications",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:15Z",
  "url": "https://research.draconitic.com/paper/cym4dc1xrge8h",
  "venue": "Frontiers in immunology",
  "versions": []
}